Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1772071..1772569 Replicon chromosome
Accession NZ_CP077259
Organism Streptococcus mitis strain FDAARGOS 1456

Toxin (Protein)


Gene name relE Uniprot ID F9HDX7
Locus tag I6L86_RS08450 Protein ID WP_004239453.1
Coordinates 1772071..1772325 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID F9HDX8
Locus tag I6L86_RS08455 Protein ID WP_000208079.1
Coordinates 1772327..1772569 (-) Length 81 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L86_RS08430 (I6L86_08430) 1767081..1768982 - 1902 WP_000584858.1 ABC-F family ATP-binding cassette domain-containing protein -
I6L86_RS08435 (I6L86_08435) 1769136..1770854 + 1719 WP_000121686.1 phospho-sugar mutase -
I6L86_RS08440 (I6L86_08440) 1770966..1771313 + 348 WP_000434630.1 thiol reductase thioredoxin -
I6L86_RS08445 (I6L86_08445) 1771351..1772055 - 705 Protein_1623 ion channel -
I6L86_RS08450 (I6L86_08450) 1772071..1772325 - 255 WP_004239453.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6L86_RS08455 (I6L86_08455) 1772327..1772569 - 243 WP_000208079.1 DUF6290 family protein Antitoxin
I6L86_RS08460 (I6L86_08460) 1772660..1773469 - 810 WP_000004960.1 MBL fold metallo-hydrolase -
I6L86_RS08465 (I6L86_08465) 1773462..1774820 - 1359 WP_000571163.1 cell wall metabolism sensor histidine kinase VicK -
I6L86_RS08470 (I6L86_08470) 1774813..1775520 - 708 WP_000722072.1 response regulator YycF -
I6L86_RS08475 (I6L86_08475) 1775576..1776751 - 1176 WP_000886130.1 A/G-specific adenine glycosylase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 85 a.a.        Molecular weight: 10112.82 Da        Isoelectric Point: 10.7632

>T206868 WP_004239453.1 NZ_CP077259:c1772325-1772071 [Streptococcus mitis]
MYKLVPTRRFIKQLKKLDRYTQKIITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVIATLEVGHR
RDIY

Download         Length: 255 bp

>T206868 NZ_CP102739:c1280715-1280458 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGAATGCCTCCGGCGCCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCACCAGTTACTCACATATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAACAGCTTTACAAGGCTGAACAGGTGGTTAAGGGGATG
CGGGACGTGATTGTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9206.40 Da        Isoelectric Point: 3.9338

>AT206868 WP_000208079.1 NZ_CP077259:c1772569-1772327 [Streptococcus mitis]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLEDE

Download         Length: 243 bp

>AT206868 NZ_CP102739:1280540-1280872 [Salmonella enterica subsp. enterica serovar Kentucky]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGG
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTTAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB F9HDX7


Antitoxin

Source ID Structure
AlphaFold DB F9HDX8

References