Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/RelE(toxin) |
Location | 1772071..1772569 | Replicon | chromosome |
Accession | NZ_CP077259 | ||
Organism | Streptococcus mitis strain FDAARGOS 1456 |
Toxin (Protein)
Gene name | relE | Uniprot ID | F9HDX7 |
Locus tag | I6L86_RS08450 | Protein ID | WP_004239453.1 |
Coordinates | 1772071..1772325 (-) | Length | 85 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | F9HDX8 |
Locus tag | I6L86_RS08455 | Protein ID | WP_000208079.1 |
Coordinates | 1772327..1772569 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
I6L86_RS08430 (I6L86_08430) | 1767081..1768982 | - | 1902 | WP_000584858.1 | ABC-F family ATP-binding cassette domain-containing protein | - |
I6L86_RS08435 (I6L86_08435) | 1769136..1770854 | + | 1719 | WP_000121686.1 | phospho-sugar mutase | - |
I6L86_RS08440 (I6L86_08440) | 1770966..1771313 | + | 348 | WP_000434630.1 | thiol reductase thioredoxin | - |
I6L86_RS08445 (I6L86_08445) | 1771351..1772055 | - | 705 | Protein_1623 | ion channel | - |
I6L86_RS08450 (I6L86_08450) | 1772071..1772325 | - | 255 | WP_004239453.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
I6L86_RS08455 (I6L86_08455) | 1772327..1772569 | - | 243 | WP_000208079.1 | DUF6290 family protein | Antitoxin |
I6L86_RS08460 (I6L86_08460) | 1772660..1773469 | - | 810 | WP_000004960.1 | MBL fold metallo-hydrolase | - |
I6L86_RS08465 (I6L86_08465) | 1773462..1774820 | - | 1359 | WP_000571163.1 | cell wall metabolism sensor histidine kinase VicK | - |
I6L86_RS08470 (I6L86_08470) | 1774813..1775520 | - | 708 | WP_000722072.1 | response regulator YycF | - |
I6L86_RS08475 (I6L86_08475) | 1775576..1776751 | - | 1176 | WP_000886130.1 | A/G-specific adenine glycosylase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10112.82 Da Isoelectric Point: 10.7632
>T206868 WP_004239453.1 NZ_CP077259:c1772325-1772071 [Streptococcus mitis]
MYKLVPTRRFIKQLKKLDRYTQKIITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVIATLEVGHR
RDIY
MYKLVPTRRFIKQLKKLDRYTQKIITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVIATLEVGHR
RDIY
Download Length: 255 bp
>T206868 NZ_CP102739:c1280715-1280458 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGAATGCCTCCGGCGCCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCACCAGTTACTCACATATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAACAGCTTTACAAGGCTGAACAGGTGGTTAAGGGGATG
CGGGACGTGATTGTTTAG
ATGAATGCCTCCGGCGCCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCACCAGTTACTCACATATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAACAGCTTTACAAGGCTGAACAGGTGGTTAAGGGGATG
CGGGACGTGATTGTTTAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 9206.40 Da Isoelectric Point: 3.9338
>AT206868 WP_000208079.1 NZ_CP077259:c1772569-1772327 [Streptococcus mitis]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLEDE
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLEDE
Download Length: 243 bp
>AT206868 NZ_CP102739:1280540-1280872 [Salmonella enterica subsp. enterica serovar Kentucky]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGG
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTTAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGG
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTTAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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