Detailed information of TA system TA206867

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): zeta-pezA/zeta-couple_hipB
• Location: 1413672..1414918
• Replicon: chromosome
• Accession: NZ_CP077259
• Organism: Streptococcus mitis strain FDAARGOS 1456

Toxin (Protein)

• Gene name: zeta
• Uniprot ID: A0A380KWA4
• Locus tag: I6L86_RS06795
• Protein ID: WP_000405376.1
• Coordinates: 1414148..1414918 (+)
• Length: 257 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: I6L86_RS06790
• Protein ID: WP_000579609.1
• Coordinates: 1413672..1414148 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L86_RS06770 (I6L86_06770)	1408687..1410435	+	1749	WP_001254284.1	ABC transporter ATP-binding protein	-
I6L86_RS06775 (I6L86_06775)	1410693..1411952	+	1260	WP_000870440.1	TRZ/ATZ family protein	-
I6L86_RS06780 (I6L86_06780)	1412203..1412703	+	501	WP_001287267.1	50S ribosomal protein L10	-
I6L86_RS06785 (I6L86_06785)	1412776..1413144	+	369	WP_001196965.1	50S ribosomal protein L7/L12	-
I6L86_RS06790 (I6L86_06790)	1413672..1414148	+	477	WP_000579609.1	type II toxin-antitoxin system antitoxin PezA	Antitoxin
I6L86_RS06795 (I6L86_06795)	1414148..1414918	+	771	WP_000405376.1	type II toxin-antitoxin system toxin PezT	Toxin
I6L86_RS06805 (I6L86_06805)	1416575..1417006	+	432	WP_025169729.1	hypothetical protein	-
I6L86_RS06810 (I6L86_06810)	1417009..1417398	+	390	Protein_1296	replication initiation protein	-
I6L86_RS06815 (I6L86_06815)	1417561..1418031	+	471	WP_000447038.1	MarR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1390060..1445205	55145

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-214)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 257 a.a.
• Molecular weight: 29394.27 Da
• Isoelectric Point: 7.2202

>T206867 WP_000405376.1 NZ_CP077259:1414148-1414918 [Streptococcus mitis]
VEIQDYTDSEFKHALERNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVRELSHLGYNLLIEGTLRTIDVPKKTAKLLKNKGYEVQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQSEELAIFERIQIYQRDRSCVYDSGEDKTSAATVLHDLLFGEWNQVEKEML
KSGEERLKDLTNRNDC

Nucleotide

• Length: 771 bp

>T206867 NZ_CP102739:c895497-894172 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGAGCCGGAAACAGCAACGTCTGGTAATTTGGATGAACGGCATCAAAGTCGGGTACTGGGAAAAAAGCAAAGGGGTAGA
CAGCTTAGAATACCTTCCTGAATGGGTTGCTGACGAACAGGGAAGGCCGCTGTCATTGTCCCTTCCTTTTACTCCCGGGA
ACCAGGTCTGGCGTGGAAATGTGGTACGTGACTATTTTGATAATTTACTGCCGGACAGCGAAGGCATACGCAGACGTCTG
GCAATGCGTTACAAGGCCGATAGCCTGGAGCCTTTTGATCTGCTGACGGAGCTGGGAAAAGACTGCGTGGGCGCGATACA
GCTGCTTCATGACGGAGATGAACCCACTGATTTATATTCCGTGAAGTATCACCCGCTTACTGAATCAGAAATTGCGGCAA
CTTTGCGTAATACCACGGAGACATTGCTACCGGGCAGGCCAGAAGATAACGACGACTTACGTTTATCTATTGCCGGTGCT
CAGGAGAAAACAGCCCTACTGTGGCATGAAGATCGGTGGTGTATGCCGGAGGGTAATACACCAACGACGCATATATTCAA
GCTACCGCTCGGACTTGTGGGGAACATGAAAGCCGACATGAGCTCGTCGGTTGAAAATGAATGGCTCTGCTCGGTACTTC
TCGGCCAGTACGGGCTCCCCGTGGCAAGAACGCAGATTGCTCACTTTGAAGATCAGAAAGCGCTGGTGGTAGAACGTTTT
GACCGAAAATGGTCAGGAGACGGACAATGGATCATTCGTTTACCCCAGGAGGATATGTGTCAGGCCCTGGGCGTTTCGCC
ATTACGAAAATATCAGGCGGACGGCGGGCCAGGTATATCGGAAATTATGGAGGTTCTGAGTAATTCAGACCGTGCTGAGC
GTGACAAAGCGCAGTTTTTTATGACGCAGATAATTTTCTGGATGATGGCCGCAACAGATGGCCACGCTAAAAATTTCAGT
ATTTCTATTGGGCCACAGGGACGTTATCACCTTACACCAAACTATGATGTGTTGTCGGCATGGCCGGTGATCGGTCATGG
GAACAATCAGATATCCTGGCAGAAGTGCAAACTGGCGATGGCCGTACGTGGCAGTAGCAACTATTACCAGATATATCGAA
TACAACGACGCCACTGGATCAGGCATGGTGAGATAACCGGCCTGAGTAAACAGCAGACAGAGGCGATGATAGAGGAAATC
ATCGCCAGAACCCCGGGTGTCATTGAACGTGTTAGCGGGCTTCTTCCGGACCAGTTCCCCCAGCAGCTTGCGGAAAGTAT
TTTTGATGGAATGAGGCAGCAATGCAGGCGCCTGGCTGAGAAATGA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18227.67 Da
• Isoelectric Point: 4.3457

>AT206867 WP_000579609.1 NZ_CP077259:1413672-1414148 [Streptococcus mitis]
MIGKNIKSLRKTHDLTQPEFAQIIGISRNSLSRYENGTSPVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp

>AT206867 NZ_CP102739:c895795-895502 [Salmonella enterica subsp. enterica serovar Kentucky]
ATCAATAATGATTACCCGTTAAACACGCTCAACCAGCTGCGTCCCTTGCTCATTGGTTTTCGCAAGGCGAATGGCCTGAC
GCAAAAAGACCTGTCCGAAAGGTTAGGCGTCACTCAACAGACATACTCACGTCTGGAAGCCAACCCTGCCAGTGCGAGCA
TTGAACGGCTATTCAAGGTGTTTTCCATCCTGGGCGTAAAAATCAGCTTCTCCTCGGCAACCACCTCTTCAGAGAGGAAG
CAGACGGAAGAAATGCTTAAATCAAACTCACCTGCACGACAGGAGGATTGGTAA

Structures

Toxin

• AlphaFold DB: A0A380KWA4