Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1239361..1239988 Replicon chromosome
Accession NZ_CP077259
Organism Streptococcus mitis strain FDAARGOS 1456

Toxin (Protein)


Gene name parE Uniprot ID I0SM96
Locus tag I6L86_RS06000 Protein ID WP_000384864.1
Coordinates 1239638..1239988 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1X1KIL2
Locus tag I6L86_RS05995 Protein ID WP_000951984.1
Coordinates 1239361..1239648 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L86_RS05970 (I6L86_05970) 1235144..1235983 + 840 WP_001192117.1 carbohydrate ABC transporter permease -
I6L86_RS05975 (I6L86_05975) 1236156..1236608 + 453 WP_000575452.1 YhcH/YjgK/YiaL family protein -
I6L86_RS05980 (I6L86_05980) 1236628..1237272 + 645 WP_000057476.1 DUF624 domain-containing protein -
I6L86_RS05985 (I6L86_05985) 1237445..1238362 + 918 WP_001281493.1 dihydrodipicolinate synthase family protein -
I6L86_RS05990 (I6L86_05990) 1238380..1239264 + 885 WP_000150262.1 ROK family protein -
I6L86_RS05995 (I6L86_05995) 1239361..1239648 + 288 WP_000951984.1 hypothetical protein Antitoxin
I6L86_RS06000 (I6L86_06000) 1239638..1239988 + 351 WP_000384864.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6L86_RS06005 (I6L86_06005) 1240050..1240901 - 852 WP_000360341.1 MurR/RpiR family transcriptional regulator -
I6L86_RS06010 (I6L86_06010) 1241093..1243150 + 2058 WP_004238750.1 penicillin-binding protein PBP2B -
I6L86_RS06015 (I6L86_06015) 1243161..1243757 + 597 WP_000966754.1 recombination mediator RecR -
I6L86_RS06020 (I6L86_06020) 1243932..1244975 + 1044 WP_000814640.1 D-alanine--D-alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-104)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13718.86 Da        Isoelectric Point: 9.8158

>T206866 WP_000384864.1 NZ_CP077259:1239638-1239988 [Streptococcus mitis]
MDYKKYRILYSPRVIDSLDKIYQYIAEEIGSVEAARRKVASIRKDINRLEIFPQAGFDADEKFGKKLDPRYQTRGLTLSK
DYIVLYTIVEDTVRLAYLLPSKSDYMKLFKTKSRYD

Download         Length: 351 bp

>T206866 NZ_CP102739:c681133-680717 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGAGTAAAACCTACATGCTGGATACCTGCATCTGTTCTTTCATTATGCGCGAACAGCCGGAAGCTGTGCTGAAACGCCT
TGAGCAGGCAGTGCTGCGCCGCCATCGTATTGTGGTGTCGGCGATTACCTACGCCGAAATGCGTTTTGGCTGTACGGGCA
AAAAGGCCTCGCCGCGCCATGCCCAACTGGTCGATGCATTCTGTAGTCGCCTGGATGCCGTGCTGGCCTGGGACCGGGCG
GCAGTGGATGCCACCACAGAGATCCGTGCCGTACTGGCCGCCGCCGGTACGCCGATTGGATCAAACGATGCTGCTATCGC
CGGCCATGCCATTGCGTCCGGGGCGATACTGGTCACTAATAACGTGAGGGAGTTTGAGCGGGTACCGGGTTTGCAGTACG
AAGATTGGGTAAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10829.20 Da        Isoelectric Point: 4.1285

>AT206866 WP_000951984.1 NZ_CP077259:1239361-1239648 [Streptococcus mitis]
MAIANSNKIVTFQANRELVNDAMEVLKEQNLSLSSALRLFLKNVAVTNEVDLLSEEELEKEYLFRQLQAEVQESYAKIEA
GNYLTDEDVVTRYGL

Download         Length: 288 bp

>AT206866 NZ_CP102739:c681360-681130 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGCGAACCGTATCTGTATTTAAAAATGGCAATAACCGCGCGATCCGCCTTCCACGCGATCTGGATTTTGACGGCGTCAA
CGAACTTGAAATCTTCCGCGAAGGCGACACGATTATACTGCGCCCCGCCCGCCCTTCCTGGGGATCATTCCGTCATGAGG
AAAAAGCCAGCCCAGACTTTCTGACGGAACGCGAAGACATCATCAGCGATGAGGGACGCTTTGAACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I0SM96

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1KIL2

References