Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | sezT-pezT/zeta-couple_hipB |
| Location | 1780028..1781271 | Replicon | chromosome |
| Accession | NZ_CP077248 | ||
| Organism | Streptococcus gordonii strain FDAARGOS 1455 | ||
Toxin (Protein)
| Gene name | sezT | Uniprot ID | - |
| Locus tag | I6L85_RS08790 | Protein ID | WP_111723271.1 |
| Coordinates | 1780028..1780795 (-) | Length | 256 a.a. |
Antitoxin (Protein)
| Gene name | pezT | Uniprot ID | A0A6I3P6W1 |
| Locus tag | I6L85_RS08795 | Protein ID | WP_046165028.1 |
| Coordinates | 1780795..1781271 (-) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6L85_RS08755 (I6L85_08755) | 1775700..1776152 | + | 453 | WP_111723272.1 | DUF3290 family protein | - |
| I6L85_RS08760 (I6L85_08760) | 1776149..1776781 | + | 633 | WP_172455857.1 | DUF421 domain-containing protein | - |
| I6L85_RS08765 (I6L85_08765) | 1776963..1777166 | + | 204 | WP_008808393.1 | CsbD family protein | - |
| I6L85_RS08775 (I6L85_08775) | 1777490..1778446 | - | 957 | WP_061583301.1 | hypothetical protein | - |
| I6L85_RS08780 (I6L85_08780) | 1779135..1779506 | - | 372 | WP_046165031.1 | type II toxin-antitoxin system death-on-curing family toxin | - |
| I6L85_RS08785 (I6L85_08785) | 1779503..1779760 | - | 258 | WP_046165030.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| I6L85_RS08790 (I6L85_08790) | 1780028..1780795 | - | 768 | WP_111723271.1 | type II toxin-antitoxin system toxin PezT | Toxin |
| I6L85_RS08795 (I6L85_08795) | 1780795..1781271 | - | 477 | WP_046165028.1 | type II toxin-antitoxin system antitoxin PezA | Antitoxin |
| I6L85_RS10610 | 1781662..1781943 | + | 282 | WP_231083267.1 | SPASM domain-containing protein | - |
| I6L85_RS08805 (I6L85_08805) | 1781927..1783444 | + | 1518 | WP_046165027.1 | ABC transporter ATP-binding protein | - |
| I6L85_RS08810 (I6L85_08810) | 1784174..1784674 | - | 501 | WP_045505588.1 | hypothetical protein | - |
| I6L85_RS08815 (I6L85_08815) | 1784822..1785010 | + | 189 | WP_000171300.1 | hypothetical protein | - |
| I6L85_RS08820 (I6L85_08820) | 1785003..1785614 | + | 612 | WP_000240415.1 | Fic family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1774864..1797562 | 22698 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 256 a.a. Molecular weight: 29184.16 Da Isoelectric Point: 7.0531
>T206864 WP_111723271.1 NZ_CP077248:c1780795-1780028 [Streptococcus gordonii]
MKLEEFSQDDFERASRRLVRSLTRGKTTSSQPKAILLGGQSGAGKTTIHRIKQREFQGNIIIIDGDSYRSFHPNYLGLQE
KYGKDSVDYTKVFAGQMVEYLVDELSKQGYHLLIEGTLRTTEVPRKTAQLLITKGYQVSLALIATKPELSYLSTLIRYEE
LYAIDSSQARATPKAHHDGIVEHMVDNLRELENDKLFRQIQIYQRDQSCVYDSQVDQISAAEVLQECLFGKWSKVEEEML
KLGQERLREMGGINK
MKLEEFSQDDFERASRRLVRSLTRGKTTSSQPKAILLGGQSGAGKTTIHRIKQREFQGNIIIIDGDSYRSFHPNYLGLQE
KYGKDSVDYTKVFAGQMVEYLVDELSKQGYHLLIEGTLRTTEVPRKTAQLLITKGYQVSLALIATKPELSYLSTLIRYEE
LYAIDSSQARATPKAHHDGIVEHMVDNLRELENDKLFRQIQIYQRDQSCVYDSQVDQISAAEVLQECLFGKWSKVEEEML
KLGQERLREMGGINK
Download Length: 768 bp
>T206864 NZ_CP102739:225996-226307 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGATCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGATCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG
Antitoxin
Download Length: 159 a.a. Molecular weight: 18054.48 Da Isoelectric Point: 4.3745
>AT206864 WP_046165028.1 NZ_CP077248:c1781271-1780795 [Streptococcus gordonii]
MIGENIKALRKTHDLTQPEFAKIVGISRNSLSRYENGTSSISTELIDRICQKFNVSYIDIVGEEKMLTPVEDYQLTLKIE
VIKERGANILAQLYRFQDEQGIAFDDTSNPWVLMSDDLSDLLNTKIYLVGTFDEVERYNGYLDGIERMLEQATHLVVA
MIGENIKALRKTHDLTQPEFAKIVGISRNSLSRYENGTSSISTELIDRICQKFNVSYIDIVGEEKMLTPVEDYQLTLKIE
VIKERGANILAQLYRFQDEQGIAFDDTSNPWVLMSDDLSDLLNTKIYLVGTFDEVERYNGYLDGIERMLEQATHLVVA
Download Length: 477 bp
>AT206864 NZ_CP102739:226308-226598 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTAAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGCTCACCGACAGGGCCAGCCAAAGCATTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTAAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGCTCACCGACAGGGCCAGCCAAAGCATTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|