Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2851437..2852056 Replicon chromosome
Accession NZ_CP077242
Organism Escherichia fergusonii strain FDAARGOS 1438

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag I6L68_RS13485 Protein ID WP_001280991.1
Coordinates 2851437..2851655 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID B7LLQ9
Locus tag I6L68_RS13490 Protein ID WP_000344803.1
Coordinates 2851682..2852056 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L68_RS13455 (2847093) 2847093..2847665 + 573 WP_000779831.1 YbaY family lipoprotein -
I6L68_RS13460 (2847696) 2847696..2848007 - 312 WP_000409911.1 MGMT family protein -
I6L68_RS13470 (2848386) 2848386..2848739 + 354 WP_000878140.1 DUF1428 domain-containing protein -
I6L68_RS13475 (2848781) 2848781..2850331 - 1551 WP_001260377.1 EAL domain-containing protein -
I6L68_RS13480 (2850470) 2850470..2850940 - 471 WP_002431406.1 YlaC family protein -
I6L68_RS13485 (2851437) 2851437..2851655 - 219 WP_001280991.1 HHA domain-containing protein Toxin
I6L68_RS13490 (2851682) 2851682..2852056 - 375 WP_000344803.1 Hha toxicity modulator TomB Antitoxin
I6L68_RS13495 (2852559) 2852559..2855708 - 3150 WP_001132493.1 efflux RND transporter permease AcrB -
I6L68_RS13500 (2855731) 2855731..2856924 - 1194 WP_002431407.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T206853 WP_001280991.1 NZ_CP077242:c2851655-2851437 [Escherichia fergusonii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T206853 NZ_CP102719:c681131-680715 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGAGTAAAACCTACATGCTGGATACCTGCATCTGTTCTTTCATTATGCGCGAACAGCCGGAAGCTGTGCTGAAACGCCT
TGAGCAGGCAGTGCTGCGCCGCCATCGTATTGTGGTGTCGGCGATTACCTACGCCGAAATGCGTTTTGGCTGTACGGGCA
AAAAGGCCTCGCCGCGCCATGCCCAACTGGTCGATGCATTCTGTAGTCGCCTGGATGCCGTGCTGGCCTGGGACCGGGCG
GCAGTGGATGCCACCACAGAGATCCGTGCCGTACTGGCCGCCGCCGGTACGCCGATTGGATCAAACGATGCTGCTATCGC
CGGCCATGCCATTGCGTCCGGGGCGATACTGGTCACTAATAACGTGAGGGAGTTTGAGCGGGTACCGGGTTTGCAGTACG
AAGATTGGGTAAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14525.33 Da        Isoelectric Point: 4.8989

>AT206853 WP_000344803.1 NZ_CP077242:c2852056-2851682 [Escherichia fergusonii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT206853 NZ_CP102719:c681358-681128 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGCGAACCGTATCTGTATTTAAAAATGGCAATAACCGCGCGATCCGCCTTCCACGCGATCTGGATTTTGACGGCGTCAA
CGAACTTGAAATCTTCCGCGAAGGCGACACGATTATACTGCGCCCCGCCCGCCCTTCCTGGGGATCATTCCGTCATGAGG
AAAAAGCCAGCCCAGACTTTCTGACGGAACGCGAAGACATCATCAGCGATGAGGGACGCTTTGAACTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A7K4HRV1

References