206839

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3834009..3834662 Replicon chromosome
Accession NZ_CP077238
Organism Acinetobacter pittii strain FDAARGOS 1399

Toxin (Protein)


Gene name cptA Uniprot ID A0A013STE4
Locus tag I6L29_RS18195 Protein ID WP_005078321.1
Coordinates 3834273..3834662 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A009HHW9
Locus tag I6L29_RS18190 Protein ID WP_002117064.1
Coordinates 3834009..3834266 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L29_RS18170 (I6L29_18170) 3829522..3830529 + 1008 WP_002116730.1 DNA-directed RNA polymerase subunit alpha -
I6L29_RS18175 (I6L29_18175) 3830548..3830925 + 378 WP_002049717.1 50S ribosomal protein L17 -
I6L29_RS18180 (I6L29_18180) 3831107..3832597 + 1491 WP_002116796.1 NAD(P)/FAD-dependent oxidoreductase -
I6L29_RS18185 (I6L29_18185) 3832648..3833820 - 1173 WP_002116790.1 acyl-CoA dehydrogenase family protein -
I6L29_RS18190 (I6L29_18190) 3834009..3834266 + 258 WP_002117064.1 succinate dehydrogenase assembly factor 2 Antitoxin
I6L29_RS18195 (I6L29_18195) 3834273..3834662 + 390 WP_005078321.1 hypothetical protein Toxin
I6L29_RS18200 (I6L29_18200) 3835433..3836521 + 1089 WP_002116869.1 hypothetical protein -
I6L29_RS18205 (I6L29_18205) 3836606..3837181 + 576 WP_005078319.1 rhombosortase -
I6L29_RS18210 (I6L29_18210) 3837361..3839571 + 2211 WP_002116854.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15476.61 Da        Isoelectric Point: 7.9230

>T206839 WP_005078321.1 NZ_CP077238:3834273-3834662 [Acinetobacter pittii]
MIKELNFELKYSLVSVIFQLFVGLGLAILLYQLLTPIWWLCAVILLFIGFIFFLKQAQISQIEYLDQKLWSVAYFSKKEI
YRAEITKIIDYQLFVVIYLEETPTNIAIVWFDQLPIQQWKRLKVLEKLY

Download         Length: 390 bp

>T206839 NZ_CP102696:2043-2321 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAACGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGAACCCGGGAACTGGTTATTCACCCCCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGTGTATTGCATACCGCACAGAAGTGGCCATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10295.73 Da        Isoelectric Point: 4.4809

>AT206839 WP_002117064.1 NZ_CP077238:3834009-3834266 [Acinetobacter pittii]
MSDEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVDQEDPDLLDWFMEVSEPPRTELREFIYKLK
QYVHG

Download         Length: 258 bp

>AT206839 NZ_CP102696:1774-2043 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCTGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATCCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAACGCGGTGATGTGCTTCCCCATGACATGGTCGAATCCTCCGCTACTGCATGGCGGGAT
GAAATGAGCAGGAAGGCCGCAGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A013STE4

Antitoxin

Source ID Structure
AlphaFold DB A0A009HHW9

References