Detailed information of TA system TA206838

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2103838..2104517
• Replicon: chromosome
• Accession: NZ_CP077238
• Organism: Acinetobacter pittii strain FDAARGOS 1399

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: I6L29_RS09915
• Protein ID: WP_000838146.1
• Coordinates: 2104335..2104517 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: I6L29_RS09910
• Protein ID: WP_000966688.1
• Coordinates: 2103838..2104242 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L29_RS09900 (I6L29_09900)	2102794..2103057	-	264	WP_001275792.1	hypothetical protein	-
I6L29_RS09905 (I6L29_09905)	2103059..2103739	-	681	WP_000721572.1	hypothetical protein	-
I6L29_RS09910 (I6L29_09910)	2103838..2104242	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
I6L29_RS09915 (I6L29_09915)	2104335..2104517	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
I6L29_RS09920 (I6L29_09920)	2104843..2105358	-	516	WP_025464105.1	hypothetical protein	-
I6L29_RS09925 (I6L29_09925)	2105429..2106346	-	918	WP_002121543.1	phage tail tube protein	-
I6L29_RS09930 (I6L29_09930)	2106399..2107727	-	1329	WP_023187966.1	hypothetical protein	-
I6L29_RS09935 (I6L29_09935)	2107727..2108080	-	354	WP_002121621.1	hypothetical protein	-
I6L29_RS09940 (I6L29_09940)	2108149..2108547	-	399	WP_002121567.1	phage tail terminator-like protein	-
I6L29_RS09945 (I6L29_09945)	2108549..2108917	-	369	WP_000539743.1	hypothetical protein	-
I6L29_RS09950 (I6L29_09950)	2108889..2109293	-	405	WP_002121581.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2084880..2140913	56033

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T206838 WP_000838146.1 NZ_CP077238:c2104517-2104335 [Acinetobacter pittii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T206838 NZ_CP102695:c57080-56700 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGCGCTGCGACTGG
CGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT206838 WP_000966688.1 NZ_CP077238:c2104242-2103838 [Acinetobacter pittii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT206838 NZ_CP102695:c57301-57080 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGTGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6