Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4002668..4004227 Replicon chromosome
Accession NZ_CP077236
Organism Lelliottia amnigena strain FDAARGOS 1444

Toxin (Protein)


Gene name hipA Uniprot ID A0A3S5XQH7
Locus tag I6L74_RS18855 Protein ID WP_059178935.1
Coordinates 4002668..4003975 (-) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A3S5XQW5
Locus tag I6L74_RS18860 Protein ID WP_012017425.1
Coordinates 4003976..4004227 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L74_RS18830 (I6L74_18830) 3998081..3998524 + 444 WP_059178931.1 cyclophilin-like fold protein -
I6L74_RS18835 (I6L74_18835) 3998888..3999175 + 288 WP_059178932.1 VF530 family protein -
I6L74_RS18840 (I6L74_18840) 3999183..4000490 + 1308 WP_174521007.1 glycoside hydrolase family 10 protein -
I6L74_RS18845 (I6L74_18845) 4000503..4001264 - 762 WP_059178933.1 thiol:disulfide interchange protein DsbG -
I6L74_RS18850 (I6L74_18850) 4001307..4002527 - 1221 WP_059178934.1 diguanylate phosphodiesterase -
I6L74_RS18855 (I6L74_18855) 4002668..4003975 - 1308 WP_059178935.1 type II toxin-antitoxin system HipA family toxin Toxin
I6L74_RS18860 (I6L74_18860) 4003976..4004227 - 252 WP_012017425.1 helix-turn-helix domain-containing protein Antitoxin
I6L74_RS18865 (I6L74_18865) 4004315..4004779 - 465 WP_059178936.1 helix-turn-helix domain-containing protein -
I6L74_RS18870 (I6L74_18870) 4004873..4006081 + 1209 WP_059178937.1 MFS transporter -
I6L74_RS18875 (I6L74_18875) 4006014..4007531 - 1518 WP_059178938.1 alpha/beta hydrolase -
I6L74_RS18880 (I6L74_18880) 4007683..4008645 + 963 WP_059178939.1 mannuronate-specific alginate lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 49182.29 Da        Isoelectric Point: 8.6915

>T206828 WP_059178935.1 NZ_CP077236:c4003975-4002668 [Lelliottia amnigena]
MKTSKLTVAMNGTVVGTLYRNGKGAMSWQYAQTWLDTPGARVISQSLPLTPRRQEGEVVYNFFSNLLPDSQAIISRMQTR
FKIPTDHPFDLLASVGRDCVGAIQLYPENSEIPPVTHMQATPLSDNEIAALLEGYRNAPLGMNDDQDFRISIAGAQEKTA
LLWHQNRWQRPNGSTPTSHIFKLPIGKIEQNNIDLSESCENEWLCLRLAREFGFSVAEATLATYADKKVLIVERFDRKWS
RDGKWLMRLPQEDMCQALGYSPALKYESHGGPGIAEIMTLLLGSRRSNQDRETFFRTQIFYWLTGAIDGHAKNYSVFIEP
DSAYVMTPLYDILSAYPVFGPKGISAQKAKMAMALQGKNRQYHWAQIQPRHFPATAERVGFSAIRAKKMMIEMGNATNEI
IERVRQSLPIDFPTHISEAIFNGMAKQAERLIRLE

Download         Length: 1308 bp

>T206828 NZ_CP102694:1031065-1031400 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9323.55 Da        Isoelectric Point: 5.0790

>AT206828 WP_012017425.1 NZ_CP077236:c4004227-4003976 [Lelliottia amnigena]
MKITTSTMLANAMRDQRKALELTQAEAAERVGMKQTTVSGFEQNPDTSKLETLFRLLSALDLELHVVPRGQASEKDSGWT
QEW

Download         Length: 252 bp

>AT206828 NZ_CP102694:1030817-1031065 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5XQH7

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5XQW5

References