Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2830260..2830880 Replicon chromosome
Accession NZ_CP077236
Organism Lelliottia amnigena strain FDAARGOS 1444

Toxin (Protein)


Gene name Hha Uniprot ID A0A2S5C408
Locus tag I6L74_RS13235 Protein ID WP_012016344.1
Coordinates 2830260..2830478 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A3S5XLQ2
Locus tag I6L74_RS13240 Protein ID WP_059177928.1
Coordinates 2830506..2830880 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L74_RS13205 (I6L74_13205) 2826266..2826526 + 261 WP_012016339.1 type B 50S ribosomal protein L31 -
I6L74_RS13210 (I6L74_13210) 2826529..2826669 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
I6L74_RS13215 (I6L74_13215) 2826666..2827376 - 711 WP_059177924.1 GNAT family protein -
I6L74_RS13220 (I6L74_13220) 2827476..2828936 + 1461 WP_059177925.1 PLP-dependent aminotransferase family protein -
I6L74_RS13225 (I6L74_13225) 2828908..2829375 - 468 WP_059177926.1 YlaC family protein -
I6L74_RS13230 (I6L74_13230) 2829494..2830045 - 552 WP_059177927.1 maltose O-acetyltransferase -
I6L74_RS13235 (I6L74_13235) 2830260..2830478 - 219 WP_012016344.1 HHA domain-containing protein Toxin
I6L74_RS13240 (I6L74_13240) 2830506..2830880 - 375 WP_059177928.1 Hha toxicity modulator TomB Antitoxin
I6L74_RS13245 (I6L74_13245) 2831389..2834538 - 3150 WP_059177929.1 multidrug efflux RND transporter permease subunit AcrB -
I6L74_RS13250 (I6L74_13250) 2834561..2835754 - 1194 WP_059177930.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8631.05 Da        Isoelectric Point: 8.9039

>T206827 WP_012016344.1 NZ_CP077236:c2830478-2830260 [Lelliottia amnigena]
MSDKPLTKTDYLMRLRRCQSLDTLERVIEKNKYELPDHELAVFYSAADHRLAELTMNKLYDKIPVSVWKFVR

Download         Length: 219 bp

>T206827 NZ_CP102694:889474-889881 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14550.26 Da        Isoelectric Point: 5.1481

>AT206827 WP_059177928.1 NZ_CP077236:c2830880-2830506 [Lelliottia amnigena]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFNNVSRANPVSHSC

Download         Length: 375 bp

>AT206827 NZ_CP102694:889227-889493 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S5C408

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5XLQ2

References