Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 2114723..2115320 Replicon chromosome
Accession NZ_CP077236
Organism Lelliottia amnigena strain FDAARGOS 1444

Toxin (Protein)


Gene name PumA Uniprot ID A0A3S5XVP2
Locus tag I6L74_RS09890 Protein ID WP_059179822.1
Coordinates 2115003..2115320 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A3S5XWI6
Locus tag I6L74_RS09885 Protein ID WP_059179821.1
Coordinates 2114723..2115010 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L74_RS09880 (I6L74_09880) 2113095..2114726 + 1632 WP_059179820.1 Na/Pi cotransporter family protein -
I6L74_RS09885 (I6L74_09885) 2114723..2115010 - 288 WP_059179821.1 putative addiction module antidote protein Antitoxin
I6L74_RS09890 (I6L74_09890) 2115003..2115320 - 318 WP_059179822.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6L74_RS09895 (I6L74_09895) 2115510..2116379 + 870 WP_059179823.1 23S rRNA pseudouridine(2604) synthase RluF -
I6L74_RS09900 (I6L74_09900) 2116380..2116652 - 273 WP_059179824.1 DUF3811 domain-containing protein -
I6L74_RS09905 (I6L74_09905) 2116715..2117659 - 945 WP_059179825.1 ketopantoate/pantoate/pantothenate transporter PanS -
I6L74_RS09910 (I6L74_09910) 2117752..2119101 - 1350 WP_059179826.1 lysine-sensitive aspartokinase 3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11914.68 Da        Isoelectric Point: 9.5735

>T206826 WP_059179822.1 NZ_CP077236:c2115320-2115003 [Lelliottia amnigena]
MKEIVQTESFRCWEQNVNDPRAKTLIAARLFRLANGLPGDVKPVGEGISELRIHYGPGYRIYFKSQGNVLIILLSGGNKN
SQDKDIILAKTLARSLEHREFIHHD

Download         Length: 318 bp

>T206826 NZ_CP102694:755357-755653 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATACCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10166.62 Da        Isoelectric Point: 5.0492

>AT206826 WP_059179821.1 NZ_CP077236:c2115010-2114723 [Lelliottia amnigena]
MTELTHYDPARALINDDEISVFMADALETGDSAYIAKALGIVARAKGMSTIATQTGLSREQLYRSFSEKGNPTLKTTLAV
MKALGLGLTIKSAED

Download         Length: 288 bp

>AT206826 NZ_CP102694:755655-756050 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5XVP2

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5XWI6

References