Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeV-yfjZ/CbtA-CbeA
Location 1071371..1072093 Replicon chromosome
Accession NZ_CP077236
Organism Lelliottia amnigena strain FDAARGOS 1444

Toxin (Protein)


Gene name yeeV Uniprot ID A0A3S5XTH1
Locus tag I6L74_RS05025 Protein ID WP_059177462.1
Coordinates 1071371..1071691 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A3S5XU25
Locus tag I6L74_RS05030 Protein ID WP_059177461.1
Coordinates 1071758..1072093 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L74_RS05005 (I6L74_05005) 1067657..1069495 + 1839 WP_041689526.1 RNA polymerase sigma factor RpoD -
I6L74_RS05010 (I6L74_05010) 1069614..1070120 - 507 WP_059177464.1 G/U mismatch-specific DNA glycosylase -
I6L74_RS05020 (I6L74_05020) 1070424..1071257 - 834 WP_059177463.1 DUF4942 domain-containing protein -
I6L74_RS05025 (I6L74_05025) 1071371..1071691 - 321 WP_059177462.1 TA system toxin CbtA family protein Toxin
I6L74_RS05030 (I6L74_05030) 1071758..1072093 - 336 WP_059177461.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6L74_RS05035 (I6L74_05035) 1072108..1072587 - 480 WP_059177460.1 DNA repair protein RadC -
I6L74_RS05040 (I6L74_05040) 1072959..1073084 - 126 Protein_976 transposase -
I6L74_RS05045 (I6L74_05045) 1073245..1074372 + 1128 WP_059177459.1 hypothetical protein -
I6L74_RS05050 (I6L74_05050) 1074377..1074925 + 549 WP_059177458.1 helix-turn-helix domain-containing protein -
I6L74_RS05055 (I6L74_05055) 1075062..1076153 + 1092 WP_059177457.1 multiubiquitin domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(13-105)

Antitoxin

Antitoxin CbeA

(7-107)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12075.72 Da        Isoelectric Point: 5.5094

>T206824 WP_059177462.1 NZ_CP077236:c1071691-1071371 [Lelliottia amnigena]
MQTSTVPVTVPVLSRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDAAIQEHIEAGITLADAVNFLVERYELVRTDRKGF
TWQEQTPFLTATDILRARRATGLINT

Download         Length: 321 bp

>T206824 NZ_CP102694:315255-315782 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12616.49 Da        Isoelectric Point: 6.4763

>AT206824 WP_059177461.1 NZ_CP077236:c1072093-1071758 [Lelliottia amnigena]
MNKDVTQTWGLKREITPCFGARLVQEGHRLHFLADWAGFTGMFSEVQALQLDEAFPHFVAHLELMLLSCELNPRYAHCVT
LYRNGLTCEADTLGSHGFVYIAIYPSKQVKD

Download         Length: 336 bp

>AT206824 NZ_CP102694:314982-315248 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCTGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5XTH1

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5XU25

References