Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 904264..904924 Replicon chromosome
Accession NZ_CP077236
Organism Lelliottia amnigena strain FDAARGOS 1444

Toxin (Protein)


Gene name cptA Uniprot ID A0A3S5XTW2
Locus tag I6L74_RS04200 Protein ID WP_059177602.1
Coordinates 904264..904677 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A3S5XU93
Locus tag I6L74_RS04205 Protein ID WP_015960306.1
Coordinates 904658..904924 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L74_RS04180 (I6L74_04180) 900260..901993 - 1734 WP_059177606.1 single-stranded-DNA-specific exonuclease RecJ -
I6L74_RS04185 (I6L74_04185) 901999..902712 - 714 WP_059177605.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6L74_RS04190 (I6L74_04190) 902741..903637 - 897 WP_059177604.1 site-specific tyrosine recombinase XerD -
I6L74_RS04195 (I6L74_04195) 903738..904259 + 522 WP_059177603.1 flavodoxin FldB -
I6L74_RS04200 (I6L74_04200) 904264..904677 - 414 WP_059177602.1 protein YgfX Toxin
I6L74_RS04205 (I6L74_04205) 904658..904924 - 267 WP_015960306.1 FAD assembly factor SdhE Antitoxin
I6L74_RS04210 (I6L74_04210) 905192..906172 + 981 WP_059177601.1 tRNA-modifying protein YgfZ -
I6L74_RS04215 (I6L74_04215) 906215..906874 - 660 WP_059177600.1 hemolysin III family protein -
I6L74_RS04220 (I6L74_04220) 907038..907349 - 312 WP_059178027.1 N(4)-acetylcytidine aminohydrolase -
I6L74_RS04225 (I6L74_04225) 907402..908133 + 732 WP_059177599.1 MurR/RpiR family transcriptional regulator -
I6L74_RS04230 (I6L74_04230) 908249..909682 + 1434 WP_059177598.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16260.13 Da        Isoelectric Point: 11.1910

>T206823 WP_059177602.1 NZ_CP077236:c904677-904264 [Lelliottia amnigena]
VVLWQSDLRVSWRSQWMSLLLHGMVAAFVLLMPWPLSYTPLWMLLLSLVVFDSVRSQRRINSCQGEIKLLMDSRLRWQGK
EWEIVGTPWMLSFGMMFRLRNVQGGRNQHLWLSADSMDADEWRDLRRMVLQQPTPGR

Download         Length: 414 bp

>T206823 NZ_CP102694:293691-293921 [Escherichia coli]
CTGGATCAGCTATTTAAATCACCTTTACCTCAAGGAATCAAATGGACTGATATAGAATCTCTGGTTAAAGCGTTAGGCGG
AGAAATTAAGGAAGGTAGGGGGTCGCGCTGTAAGTTCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGT
CGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTGCGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10528.00 Da        Isoelectric Point: 5.1340

>AT206823 WP_015960306.1 NZ_CP077236:c904924-904658 [Lelliottia amnigena]
MDISNKARIHWACRRGMRELDISVMPFFEYEYDSLSDDDKRLFIRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT206823 NZ_CP102694:293918-294277 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5XTW2

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5XU93

References