Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 665138..665857 Replicon chromosome
Accession NZ_CP077236
Organism Lelliottia amnigena strain FDAARGOS 1444

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2A7T6H5
Locus tag I6L74_RS03125 Protein ID WP_004390416.1
Coordinates 665537..665857 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A2A7T740
Locus tag I6L74_RS03120 Protein ID WP_032819787.1
Coordinates 665138..665503 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L74_RS03085 (I6L74_03085) 660271..660894 - 624 WP_032819788.1 inovirus Gp2 family protein -
I6L74_RS03090 (I6L74_03090) 661488..661922 + 435 WP_004390423.1 hypothetical protein -
I6L74_RS03095 (I6L74_03095) 661891..662745 + 855 WP_254204912.1 hypothetical protein -
I6L74_RS03100 (I6L74_03100) 662796..662975 + 180 WP_004390421.1 hypothetical protein -
I6L74_RS03105 (I6L74_03105) 663515..664336 + 822 WP_004390419.1 DUF932 domain-containing protein -
I6L74_RS03110 (I6L74_03110) 664406..664876 + 471 WP_059177775.1 DNA repair protein RadC -
I6L74_RS03115 (I6L74_03115) 664885..665106 + 222 WP_059177774.1 DUF987 domain-containing protein -
I6L74_RS03120 (I6L74_03120) 665138..665503 + 366 WP_032819787.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6L74_RS03125 (I6L74_03125) 665537..665857 + 321 WP_004390416.1 TA system toxin CbtA family protein Toxin
I6L74_RS03130 (I6L74_03130) 666477..667331 + 855 WP_059177773.1 PA4780 family RIO1-like protein kinase -
I6L74_RS03135 (I6L74_03135) 667486..667641 + 156 WP_164841588.1 hypothetical protein -
I6L74_RS03140 (I6L74_03140) 667771..668127 + 357 WP_059177772.1 hypothetical protein -
I6L74_RS03145 (I6L74_03145) 668247..668798 + 552 WP_059177771.1 YceI family protein -
I6L74_RS03150 (I6L74_03150) 668793..669581 - 789 WP_059177770.1 hypothetical protein -
I6L74_RS03155 (I6L74_03155) 669578..670054 - 477 WP_059177769.1 sigma-70 family RNA polymerase sigma factor -
I6L74_RS03160 (I6L74_03160) 670114..670659 - 546 WP_059177768.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-105)

Antitoxin

Antitoxin CbeA

(18-116)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12131.83 Da        Isoelectric Point: 6.2084

>T206822 WP_004390416.1 NZ_CP077236:665537-665857 [Lelliottia amnigena]
MHISTVPATVPVSPRLSPVQVWQQLLTYLLEHHYGLTLNDTPFHDDSAIQEHIEAGITLADAVNFLVERYELVRIDRKGF
TWQEQTPFLTTIDLLRARRATGLVHT

Download         Length: 321 bp

>T206822 NZ_CP102693:c128392-127910 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAAACAGTCCTCGA
TGAATGGCTAAAACACAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCGAGACGGGGACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCTACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTTCACGATGCCGTTCTACGCTGTTATCGCGTAGCTGAGAATATTGGCGTCCGTGCGATAATGGTTCACGCGCTTACTG
AAGAAGCTAAAGGCTTCTATACTCACCATGGATTTACGGCATCGCAAACTCATGAGCGGACTCTGTTCCTAAAACTTCCA
TGA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13476.24 Da        Isoelectric Point: 6.0589

>AT206822 WP_032819787.1 NZ_CP077236:665138-665503 [Lelliottia amnigena]
MQSTTLSGSSAENASCLQWGLKRNITPCFGARLVQEGNRLYFLTDRAGFDGSFSDDEALRLDQVFPLMMKQLERMLTTGE
LDPRCQHCVTLHHNGLTCEADTLGSHGYVYIAIYPQSAVTR

Download         Length: 366 bp

>AT206822 NZ_CP102693:c128646-128380 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCAGCTGCAGAGATCCTTCA
TAAATCGCGTACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A7T6H5

Antitoxin

Source ID Structure
AlphaFold DB A0A2A7T740

References