Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 10110..10694 Replicon plasmid unnamed1
Accession NZ_CP077233
Organism Acinetobacter pittii strain FDAARGOS 1397

Toxin (Protein)


Gene name PumA Uniprot ID N9JY46
Locus tag I6L27_RS19320 Protein ID WP_000286963.1
Coordinates 10392..10694 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag I6L27_RS19315 Protein ID WP_000985610.1
Coordinates 10110..10391 (-) Length 94 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L27_RS19275 (I6L27_19275) 5660..5944 + 285 WP_005071539.1 putative quinol monooxygenase -
I6L27_RS19280 (I6L27_19280) 6120..6290 + 171 Protein_7 IS3 family transposase -
I6L27_RS19285 (I6L27_19285) 6288..6383 + 96 Protein_8 DNA-binding protein -
I6L27_RS19290 (I6L27_19290) 6791..7153 + 363 Protein_9 plasmid replication DNA-binding protein -
I6L27_RS19295 (I6L27_19295) 7402..7758 - 357 WP_086376473.1 hypothetical protein -
I6L27_RS19300 (I6L27_19300) 7874..8260 + 387 WP_086376474.1 hypothetical protein -
I6L27_RS19305 (I6L27_19305) 8357..8596 - 240 WP_017482479.1 hypothetical protein -
I6L27_RS19310 (I6L27_19310) 8822..10012 - 1191 WP_086376830.1 hypothetical protein -
I6L27_RS19315 (I6L27_19315) 10110..10391 - 282 WP_000985610.1 putative addiction module antidote protein Antitoxin
I6L27_RS19320 (I6L27_19320) 10392..10694 - 303 WP_000286963.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6L27_RS19325 (I6L27_19325) 10809..11327 - 519 WP_086376831.1 tetratricopeptide repeat protein -
I6L27_RS19330 (I6L27_19330) 11543..12154 - 612 WP_000571899.1 recombinase family protein -
I6L27_RS19335 (I6L27_19335) 12493..13323 + 831 WP_086376832.1 oxidoreductase -
I6L27_RS19340 (I6L27_19340) 13370..14365 + 996 WP_086376833.1 AraC family transcriptional regulator -
I6L27_RS19345 (I6L27_19345) 14382..14894 + 513 WP_086376834.1 hypothetical protein -
I6L27_RS19350 (I6L27_19350) 15049..15561 + 513 WP_001089572.1 SMI1/KNR4 family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..69574 69574


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 101 a.a.        Molecular weight: 11545.02 Da        Isoelectric Point: 4.6838

>T206819 WP_000286963.1 NZ_CP077233:c10694-10392 [Acinetobacter pittii]
MYSIYTTEAFDDWFTKLKDQQAKRRIQVRIDRVEDGNFGDTEPVGEGVSELRFFFGPGYRIYYCKQGQRVVILLAGGDKS
TQSKDIKLALQLAQDLEEEL

Download         Length: 303 bp

>T206819 NZ_CP102692:c5187237-5186854 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10109.67 Da        Isoelectric Point: 8.0018

>AT206819 WP_000985610.1 NZ_CP077233:c10391-10110 [Acinetobacter pittii]
MAIKLRKWDSAEHLKTEEDMQAYLQACIDESNGDAAFIAKALGNIAKAKGMAQLSRDTGLGRESLYKALSGDVNPSFDTV
IKVVKALNLRLAI

Download         Length: 282 bp

>AT206819 NZ_CP102692:c5187479-5187237 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A836MGN2


Antitoxin

Source ID Structure

References