Detailed information of TA system TA206818

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 3645240..3645893
• Replicon: chromosome
• Accession: NZ_CP077232
• Organism: Acinetobacter pittii strain FDAARGOS 1397

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: I6L27_RS17265
• Protein ID: WP_216967722.1
• Coordinates: 3645504..3645893 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A009HHW9
• Locus tag: I6L27_RS17260
• Protein ID: WP_002117064.1
• Coordinates: 3645240..3645497 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L27_RS17240 (I6L27_17245)	3640753..3641760	+	1008	WP_002116730.1	DNA-directed RNA polymerase subunit alpha	-
I6L27_RS17245 (I6L27_17250)	3641779..3642156	+	378	WP_002049717.1	50S ribosomal protein L17	-
I6L27_RS17250 (I6L27_17255)	3642338..3643828	+	1491	WP_031949423.1	NAD(P)/FAD-dependent oxidoreductase	-
I6L27_RS17255 (I6L27_17260)	3643879..3645051	-	1173	WP_016143559.1	acyl-CoA dehydrogenase family protein	-
I6L27_RS17260 (I6L27_17265)	3645240..3645497	+	258	WP_002117064.1	succinate dehydrogenase assembly factor 2	Antitoxin
I6L27_RS17265 (I6L27_17270)	3645504..3645893	+	390	WP_216967722.1	hypothetical protein	Toxin
I6L27_RS17270 (I6L27_17275)	3646664..3647752	+	1089	WP_216967723.1	hypothetical protein	-
I6L27_RS17275 (I6L27_17280)	3647837..3648412	+	576	WP_057105657.1	rhombosortase	-
I6L27_RS17280 (I6L27_17285)	3648592..3650787	+	2196	WP_016143554.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15491.57 Da
• Isoelectric Point: 8.7426

>T206818 WP_216967722.1 NZ_CP077232:3645504-3645893 [Acinetobacter pittii]
MIKELNFELKYSRVSVIFQLFVGLGLAILLYQLLMPIWWLCAVIFIFIGFIFFLKQTQISQIEYLDQKLWSVAYYSEKAV
HLVEIRKIIDYQMFVVIYFEGTSAKVATVWFDQLSIEQWKRLKVLEKLY

Nucleotide

• Length: 390 bp

>T206818 NZ_CP102692:c4874828-4873911 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10295.73 Da
• Isoelectric Point: 4.4809

>AT206818 WP_002117064.1 NZ_CP077232:3645240-3645497 [Acinetobacter pittii]
MSDEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVDQEDPDLLDWFMEVSEPPRTELREFIYKLK
QYVHG

Nucleotide

• Length: 258 bp

>AT206818 NZ_CP102692:c4875592-4874834 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTTGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A009HHW9