Detailed information of TA system TA206817

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1144418..1146054
• Replicon: chromosome
• Accession: NZ_CP077232
• Organism: Acinetobacter pittii strain FDAARGOS 1397

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: I6L27_RS05430
• Protein ID: WP_216968547.1
• Coordinates: 1144418..1145749 (+)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A151YPT4
• Locus tag: I6L27_RS05435
• Protein ID: WP_031948346.1
• Coordinates: 1145746..1146054 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L27_RS05410 (I6L27_05410)	1140641..1141804	+	1164	WP_216968540.1	hypothetical protein	-
I6L27_RS05415 (I6L27_05415)	1142036..1143007	+	972	WP_216968542.1	5'/3'-nucleotidase SurE	-
I6L27_RS05420 (I6L27_05420)	1143020..1143664	+	645	WP_216968544.1	hypothetical protein	-
I6L27_RS05425 (I6L27_05425)	1143700..1144140	-	441	WP_216968546.1	HD domain-containing protein	-
I6L27_RS05430 (I6L27_05430)	1144418..1145749	+	1332	WP_216968547.1	HipA domain-containing protein	Toxin
I6L27_RS05435 (I6L27_05435)	1145746..1146054	+	309	WP_031948346.1	helix-turn-helix transcriptional regulator	Antitoxin
I6L27_RS05440 (I6L27_05440)	1146754..1147308	+	555	WP_216968549.1	TetR/AcrR family transcriptional regulator	-
I6L27_RS05445 (I6L27_05445)	1147362..1148033	+	672	WP_216968551.1	HEPN domain-containing protein	-
I6L27_RS05450 (I6L27_05450)	1148213..1148482	+	270	WP_216968552.1	protein L	-
I6L27_RS05455 (I6L27_05455)	1148610..1148795	+	186	WP_216968553.1	hypothetical protein	-
I6L27_RS05460 (I6L27_05460)	1149106..1149624	+	519	WP_216968554.1	GNAT family N-acetyltransferase	-
I6L27_RS05465 (I6L27_05465)	1149721..1150563	-	843	WP_216968555.1	SDR family NAD(P)-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-359)

Antitoxin

• Cro/C1-type helix-turn-helix domain (29-82)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51098.08 Da
• Isoelectric Point: 5.0444

>T206817 WP_216968547.1 NZ_CP077232:1144418-1145749 [Acinetobacter pittii]
MKKLTIQALLNKNWLDVAELKLLEPKLGSASASELEYELDYAIQYLDRRDEYACSLSLPVQILIKHESNTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPTLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEHKVWIDTYQENFDQPDQHYLVKFPRNKRSAIDCDILRAEYYYYQVLNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWRDQSWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSINSDFDVPQFICEWLQRDLL
NIIFGNSDNHGRNTSFLKHSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDISLATLK
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T206817 NZ_CP102692:c4717503-4717219 [Klebsiella pneumoniae]
ATGACCTATGAACTGGCGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGCCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11546.46 Da
• Isoelectric Point: 9.9701

>AT206817 WP_031948346.1 NZ_CP077232:1145746-1146054 [Acinetobacter pittii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYATLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHGHIVDKIIKPSE

Nucleotide

• Length: 309 bp

>AT206817 NZ_CP102692:c4717735-4717493 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A151YPT4