Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 421409..421998 Replicon chromosome
Accession NZ_CP077232
Organism Acinetobacter pittii strain FDAARGOS 1397

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag I6L27_RS01985 Protein ID WP_216968046.1
Coordinates 421696..421998 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag I6L27_RS01980 Protein ID WP_216968045.1
Coordinates 421409..421699 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L27_RS01960 (I6L27_01960) 417072..417380 + 309 WP_216967886.1 hypothetical protein -
I6L27_RS01965 (I6L27_01965) 417380..419056 + 1677 WP_216967887.1 phage terminase large subunit -
I6L27_RS19940 419066..419962 + 897 WP_228736919.1 hypothetical protein -
I6L27_RS01975 (I6L27_01975) 420153..421379 + 1227 WP_216968044.1 hypothetical protein -
I6L27_RS01980 (I6L27_01980) 421409..421699 - 291 WP_216968045.1 putative addiction module antidote protein Antitoxin
I6L27_RS01985 (I6L27_01985) 421696..421998 - 303 WP_216968046.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6L27_RS01990 (I6L27_01990) 422088..422372 - 285 WP_216968047.1 Arc family DNA-binding protein -
I6L27_RS01995 (I6L27_01995) 422654..423112 + 459 WP_216968048.1 hypothetical protein -
I6L27_RS02000 (I6L27_02000) 423109..423804 + 696 WP_216968049.1 Rha family transcriptional regulator -
I6L27_RS02005 (I6L27_02005) 423882..424172 + 291 WP_216968050.1 hypothetical protein -
I6L27_RS02010 (I6L27_02010) 424247..424603 + 357 WP_000138209.1 hypothetical protein -
I6L27_RS02015 (I6L27_02015) 424600..424818 + 219 WP_001083663.1 hypothetical protein -
I6L27_RS02020 (I6L27_02020) 424808..425362 + 555 WP_216968051.1 lysozyme -
I6L27_RS02025 (I6L27_02025) 425487..425684 + 198 WP_005138422.1 hypothetical protein -
I6L27_RS02035 (I6L27_02035) 425939..426559 - 621 WP_216968052.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - adeH / adeG / adeF 381913..440794 58881


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Uncharacterized protein HI1420

(4-93)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11422.75 Da        Isoelectric Point: 4.4065

>T206816 WP_216968046.1 NZ_CP077232:c421998-421696 [Acinetobacter pittii]
MYEIKTTETFDEWFDSLRDTQGKARINARLRRVELGNFGDAEPVGENVSELRFFFGPGYRVYFIQEGDEIIVLLAGGDKS
SQQKDIDKAIELAKEIRGES

Download         Length: 303 bp

>T206816 NZ_CP102692:c4597840-4597307 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGTATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10645.16 Da        Isoelectric Point: 6.7258

>AT206816 WP_216968045.1 NZ_CP077232:c421699-421409 [Acinetobacter pittii]
MTVKLKKWNIQDHLKTEEERQAYLEAALEEASDDPLYIAHVLGDIAKSYGMTKLAQETGLTREGLYKSFGKQGNPSFVTV
SKVAGAMGLKLTFEHA

Download         Length: 291 bp

>AT206816 NZ_CP102692:c4598117-4597851 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References