Detailed information of TA system TA206815

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 3651336..3652909
• Replicon: chromosome
• Accession: NZ_CP077214
• Organism: Aeromonas sp. FDAARGOS 1411

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: I6L41_RS16495
• Protein ID: WP_193861257.1
• Coordinates: 3651336..3652655 (-)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A3Q8DTG9
• Locus tag: I6L41_RS16500
• Protein ID: WP_042047685.1
• Coordinates: 3652655..3652909 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L41_RS16480 (I6L41_16480)	3647254..3648018	+	765	WP_216960094.1	ATP-binding cassette domain-containing protein	-
I6L41_RS16485 (I6L41_16485)	3648052..3648936	+	885	WP_216963988.1	ABC transporter substrate-binding protein	-
I6L41_RS16490 (I6L41_16490)	3648933..3650915	+	1983	WP_216960097.1	Fe(3+)-hydroxamate ABC transporter permease FhuB	-
I6L41_RS16495 (I6L41_16495)	3651336..3652655	-	1320	WP_193861257.1	type II toxin-antitoxin system HipA family toxin	Toxin
I6L41_RS16500 (I6L41_16500)	3652655..3652909	-	255	WP_042047685.1	helix-turn-helix domain-containing protein	Antitoxin
I6L41_RS16505 (I6L41_16505)	3653448..3654065	+	618	WP_104016778.1	recombinase family protein	-
I6L41_RS16510 (I6L41_16510)	3654062..3654385	-	324	WP_104016729.1	hypothetical protein	-
I6L41_RS16515 (I6L41_16515)	3654897..3655628	-	732	WP_104016779.1	SprT family zinc-dependent metalloprotease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 49688.72 Da
• Isoelectric Point: 6.5920

>T206815 WP_193861257.1 NZ_CP077214:c3652655-3651336 [Aeromonas sp. FDAARGOS 1411]
MANLAVYMNGYRVGTFTKTTSGAHQFQYRESWLAQPGSRPISLSMPLRHQPYRGDEAYNFFDNLLPDNMEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYLDDRWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYENHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYAIEQIFPRHFFQTAKAVGFERSAMEEILTELANSV
DDVIERVTQQLPADFPDTISSTILEGLKARSARLIKGWD

Nucleotide

• Length: 1320 bp

>T206815 NZ_CP102692:3967816-3968034 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9293.62 Da
• Isoelectric Point: 7.9834

>AT206815 WP_042047685.1 NZ_CP077214:c3652909-3652655 [Aeromonas sp. FDAARGOS 1411]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSLDIKPRNESSDSPASGW
KEEW

Nucleotide

• Length: 255 bp

>AT206815 NZ_CP102692:3967415-3967789 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGGTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A3Q8DTG9