Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 126744..127270 Replicon plasmid unnamed1
Accession NZ_CP077212
Organism Enterobacter cloacae strain FDAARGOS 1431

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag I6L61_RS26570 Protein ID WP_000323025.1
Coordinates 126983..127270 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID J5W3H0
Locus tag I6L61_RS26565 Protein ID WP_004196370.1
Coordinates 126744..126983 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L61_RS26540 (122012) 122012..123388 + 1377 WP_004196363.1 chromate efflux transporter -
I6L61_RS26545 (123419) 123419..124108 - 690 WP_013087175.1 hypothetical protein -
I6L61_RS26550 (124122) 124122..124859 - 738 WP_008460272.1 HupE/UreJ family protein -
I6L61_RS26555 (124903) 124903..125268 - 366 WP_009651956.1 hypothetical protein -
I6L61_RS27700 (126621) 126621..126719 - 99 Protein_149 hypothetical protein -
I6L61_RS26565 (126744) 126744..126983 + 240 WP_004196370.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
I6L61_RS26570 (126983) 126983..127270 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
I6L61_RS26575 (127337) 127337..128092 - 756 Protein_152 IS481-like element ISKpn28 family transposase -
I6L61_RS26585 (129342) 129342..129623 - 282 Protein_154 helix-turn-helix domain-containing protein -
I6L61_RS26590 (129695) 129695..129853 + 159 WP_013087178.1 type I toxin-antitoxin system Hok family toxin -
I6L61_RS26595 (130729) 130729..131043 + 315 WP_044157807.1 hypothetical protein -
I6L61_RS26600 (131104) 131104..131565 + 462 WP_013087181.1 hypothetical protein -
I6L61_RS26605 (131653) 131653..131853 + 201 WP_013087182.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..199566 199566
- inside IScluster/Tn - - 125304..129623 4319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T206813 WP_000323025.1 NZ_CP077212:126983-127270 [Enterobacter cloacae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T206813 NZ_CP102692:1890284-1890386 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9018.43 Da        Isoelectric Point: 4.3894

>AT206813 WP_004196370.1 NZ_CP077212:126744-126983 [Enterobacter cloacae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLCNPKPVRVTLDEL

Download         Length: 240 bp

>AT206813 NZ_CP102692:c1890393-1890248 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4QRH4

References