Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 923976..924580 Replicon chromosome
Accession NZ_CP077211
Organism Enterobacter cloacae strain FDAARGOS 1431

Toxin (Protein)


Gene name hicA Uniprot ID A0A421IJD5
Locus tag I6L61_RS04320 Protein ID WP_071843252.1
Coordinates 924395..924580 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7Z1F6W0
Locus tag I6L61_RS04315 Protein ID WP_013094943.1
Coordinates 923976..924380 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L61_RS04300 (I6L61_04300) 919561..920379 - 819 WP_013094946.1 helix-turn-helix domain-containing protein -
I6L61_RS04305 (I6L61_04305) 920604..921956 + 1353 WP_013094945.1 MFS transporter -
I6L61_RS04310 (I6L61_04310) 921967..923922 + 1956 WP_013094944.1 glycoside hydrolase family 127 protein -
I6L61_RS04315 (I6L61_04315) 923976..924380 - 405 WP_013094943.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
I6L61_RS04320 (I6L61_04320) 924395..924580 - 186 WP_071843252.1 type II toxin-antitoxin system HicA family toxin Toxin
I6L61_RS04325 (I6L61_04325) 924791..925531 - 741 WP_013094942.1 MipA/OmpV family protein -
I6L61_RS04330 (I6L61_04330) 925649..926614 + 966 WP_013094941.1 LysR family transcriptional regulator -
I6L61_RS04335 (I6L61_04335) 926611..928149 - 1539 WP_013094940.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6859.08 Da        Isoelectric Point: 11.7891

>T206796 WP_071843252.1 NZ_CP077211:c924580-924395 [Enterobacter cloacae]
VKSADVITVLVRHGWKCVRTKGSHHQFRHPVHAGLVTVPHPKKDIKPGTLAQIWRQAGIKH

Download         Length: 186 bp

>T206796 NZ_CP102682:2482078-2482479 [Leptospira borgpetersenii serovar Javanica]
ATGACTCAATACTTATTAGATACGAATATTTGCATTTATATAATAAACCAAAAGCCGAGATCTGTTTATAAAAAATTTAA
AAAGATCAAGTTAGAAAACATATTTATTTCATCAATTACGGAATTTGAATTAAAGTATGGTGTTCAAAAAAGTCTTCATT
TCGAAAGGAACTTAAAAATTTTAGAAGAGTTTTTAAGTTATTTGAATATTCTTTCATTTGTTAGTGAAGACGCAAATAAA
GCTGCAAAAATTCGAGTAGAATTAGACAAAGTAGGGAAACCAATCGGTCCTTTCGATCTTTTAATAGCTTCTCAAGCGTT
ATCGAATAAACTTACTCTCGTAACAAACAATGAAAAAGAGTTTACTCGGATCAAAGATATTAAAATTGCAAACTGGCTTT
AA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14915.74 Da        Isoelectric Point: 4.3036

>AT206796 WP_013094943.1 NZ_CP077211:c924380-923976 [Enterobacter cloacae]
MFYPAYIHSDPDGSASGFFPDVPGCFFAGNSLDDAFQDARDALTAHFEALFEMDEELPLPGNVEAHLEATPGDFIGGQWL
LVDINMKQFDGKAERINITLPRRLLVKIDSFVNEHPQFSNRSAFLAEAARRVLP

Download         Length: 405 bp

>AT206796 NZ_CP102682:2481851-2482081 [Leptospira borgpetersenii serovar Javanica]
ATGAATAAAGCTAAAATTTTTAAAAATGGGGATAGTCAAGCAATTCGTTTACCGAAAGACTATCGTTTCAAAGGCAAAGA
AGTCTATATACGAAGGGATGGAGATAATGTTATCTTAACACCAATAAACGATGCGGTTGATCGTTTTTGGAATACGGTTA
ATAGCTTTTCTGACGATCTTATACTTGATCGAAACCAACCAAACGAGTATGGCAAACGAAATAAAATATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A421IJD5

Antitoxin

Source ID Structure
AlphaFold DB A0A7Z1F6W0

References