Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3819466..3820123 Replicon chromosome
Accession NZ_CP077206
Organism Enterobacter bugandensis strain FDAARGOS 1427

Toxin (Protein)


Gene name cptA Uniprot ID A0A2J7SFN6
Locus tag I6L57_RS18045 Protein ID WP_028014322.1
Coordinates 3819466..3819876 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag I6L57_RS18050 Protein ID WP_010435322.1
Coordinates 3819857..3820123 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L57_RS18025 (I6L57_18025) 3815459..3817192 - 1734 WP_041908356.1 single-stranded-DNA-specific exonuclease RecJ -
I6L57_RS18030 (I6L57_18030) 3817198..3817911 - 714 WP_049136419.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6L57_RS18035 (I6L57_18035) 3817940..3818836 - 897 WP_028014320.1 site-specific tyrosine recombinase XerD -
I6L57_RS18040 (I6L57_18040) 3818938..3819459 + 522 WP_041908355.1 flavodoxin FldB -
I6L57_RS18045 (I6L57_18045) 3819466..3819876 - 411 WP_028014322.1 protein YgfX Toxin
I6L57_RS18050 (I6L57_18050) 3819857..3820123 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
I6L57_RS18055 (I6L57_18055) 3820418..3821398 + 981 WP_048960833.1 tRNA-modifying protein YgfZ -
I6L57_RS18060 (I6L57_18060) 3821486..3822145 - 660 WP_023331242.1 hemolysin III family protein -
I6L57_RS18065 (I6L57_18065) 3822411..3823142 + 732 WP_028014325.1 MurR/RpiR family transcriptional regulator -
I6L57_RS18070 (I6L57_18070) 3823259..3824692 + 1434 WP_059358111.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16024.98 Da        Isoelectric Point: 11.2845

>T206789 WP_028014322.1 NZ_CP077206:c3819876-3819466 [Enterobacter bugandensis]
VVLWQSDLRVSWRSQWMSLLLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGVPWMLNAGMMLRLRKVGGGRCQHLWLAADSMDASEWRDLRRMLLQQPTQE

Download         Length: 411 bp

>T206789 NZ_CP102679:c4425750-4425439 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT206789 WP_010435322.1 NZ_CP077206:c3820123-3819857 [Enterobacter bugandensis]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT206789 NZ_CP102679:c4425438-4425148 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J7SFN6

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References