Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | kacAT/DUF1778(antitoxin) |
| Location | 1679923..1680720 | Replicon | chromosome |
| Accession | NZ_CP077206 | ||
| Organism | Enterobacter bugandensis strain FDAARGOS 1427 | ||
Toxin (Protein)
| Gene name | KacT | Uniprot ID | - |
| Locus tag | I6L57_RS07950 | Protein ID | WP_172616463.1 |
| Coordinates | 1680220..1680720 (+) | Length | 167 a.a. |
Antitoxin (Protein)
| Gene name | KacA | Uniprot ID | W7PG43 |
| Locus tag | I6L57_RS07945 | Protein ID | WP_008499829.1 |
| Coordinates | 1679923..1680192 (+) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6L57_RS07915 (I6L57_07915) | 1675553..1675996 | - | 444 | WP_028012647.1 | helix-turn-helix domain-containing protein | - |
| I6L57_RS07920 (I6L57_07920) | 1676149..1677390 | + | 1242 | WP_088204980.1 | bifunctional glucose-1-phosphatase/inositol phosphatase | - |
| I6L57_RS07925 (I6L57_07925) | 1677424..1677651 | - | 228 | WP_028012649.1 | YccJ family protein | - |
| I6L57_RS07930 (I6L57_07930) | 1677670..1678266 | - | 597 | WP_041910554.1 | NAD(P)H:quinone oxidoreductase | - |
| I6L57_RS07935 (I6L57_07935) | 1678657..1678827 | + | 171 | WP_001273664.1 | general stress protein | - |
| I6L57_RS07940 (I6L57_07940) | 1678944..1679861 | + | 918 | WP_088204981.1 | DMT family transporter | - |
| I6L57_RS07945 (I6L57_07945) | 1679923..1680192 | + | 270 | WP_008499829.1 | DUF1778 domain-containing protein | Antitoxin |
| I6L57_RS07950 (I6L57_07950) | 1680220..1680720 | + | 501 | WP_172616463.1 | GNAT family N-acetyltransferase | Toxin |
| I6L57_RS07955 (I6L57_07955) | 1680779..1682101 | - | 1323 | WP_048959639.1 | pyrimidine utilization transport protein G | - |
| I6L57_RS07960 (I6L57_07960) | 1682123..1682617 | - | 495 | WP_028012654.1 | pyrimidine utilization flavin reductase protein F | - |
| I6L57_RS07965 (I6L57_07965) | 1682627..1683217 | - | 591 | WP_041910551.1 | malonic semialdehyde reductase | - |
| I6L57_RS07970 (I6L57_07970) | 1683227..1684027 | - | 801 | WP_028012656.1 | pyrimidine utilization protein D | - |
| I6L57_RS07975 (I6L57_07975) | 1684035..1684421 | - | 387 | WP_088204983.1 | pyrimidine utilization protein C | - |
| I6L57_RS07980 (I6L57_07980) | 1684433..1685122 | - | 690 | WP_028012657.1 | pyrimidine utilization protein B | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 167 a.a. Molecular weight: 18873.63 Da Isoelectric Point: 8.4785
>T206780 WP_172616463.1 NZ_CP077206:1680220-1680720 [Enterobacter bugandensis]
MFSEGTDYDFGDFDCGEPSLNAFLREHLVRQHNGRILRAYLLKERDHPRVLGYYTLSGSCFERAMLPSKTQQRRIPYLNV
PSVTLGRLAIHKELQGNEWGTTLVAHAMRVVYLASQAVGVHGIFVDALSEQAKRFYLKLGFIPLAGENSHSLFFPTKAIE
RLFEQA
MFSEGTDYDFGDFDCGEPSLNAFLREHLVRQHNGRILRAYLLKERDHPRVLGYYTLSGSCFERAMLPSKTQQRRIPYLNV
PSVTLGRLAIHKELQGNEWGTTLVAHAMRVVYLASQAVGVHGIFVDALSEQAKRFYLKLGFIPLAGENSHSLFFPTKAIE
RLFEQA
Download Length: 501 bp
>T206780 NZ_CP077206:1680220-1680720 [Enterobacter bugandensis]
ATGTTTTCAGAGGGAACCGACTATGATTTCGGGGATTTTGATTGTGGTGAACCCTCGCTAAATGCCTTCCTGAGAGAACA
CCTGGTACGCCAGCACAATGGACGTATTCTACGAGCCTACCTGCTTAAAGAGCGCGACCATCCGCGCGTGCTGGGCTATT
ACACGCTATCGGGAAGTTGCTTTGAGAGAGCGATGCTTCCTTCTAAGACCCAGCAGCGTCGGATCCCTTATCTCAACGTA
CCCAGCGTGACGCTGGGACGTCTGGCTATTCATAAAGAACTACAGGGAAACGAGTGGGGAACAACGCTTGTTGCACACGC
TATGCGGGTGGTTTACCTGGCGTCGCAGGCTGTGGGAGTACATGGAATATTTGTTGATGCCCTTAGCGAGCAGGCTAAAC
GATTTTATCTGAAGCTGGGGTTCATCCCGCTGGCAGGCGAAAACAGCCATTCTTTGTTCTTCCCGACAAAAGCTATCGAA
CGACTGTTTGAGCAGGCGTGA
ATGTTTTCAGAGGGAACCGACTATGATTTCGGGGATTTTGATTGTGGTGAACCCTCGCTAAATGCCTTCCTGAGAGAACA
CCTGGTACGCCAGCACAATGGACGTATTCTACGAGCCTACCTGCTTAAAGAGCGCGACCATCCGCGCGTGCTGGGCTATT
ACACGCTATCGGGAAGTTGCTTTGAGAGAGCGATGCTTCCTTCTAAGACCCAGCAGCGTCGGATCCCTTATCTCAACGTA
CCCAGCGTGACGCTGGGACGTCTGGCTATTCATAAAGAACTACAGGGAAACGAGTGGGGAACAACGCTTGTTGCACACGC
TATGCGGGTGGTTTACCTGGCGTCGCAGGCTGTGGGAGTACATGGAATATTTGTTGATGCCCTTAGCGAGCAGGCTAAAC
GATTTTATCTGAAGCTGGGGTTCATCCCGCTGGCAGGCGAAAACAGCCATTCTTTGTTCTTCCCGACAAAAGCTATCGAA
CGACTGTTTGAGCAGGCGTGA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10262.72 Da Isoelectric Point: 5.8836
>AT206780 WP_008499829.1 NZ_CP077206:1679923-1680192 [Enterobacter bugandensis]
MPALKKQRIDLRLTDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIDNPPEPNERLKR
AAKRLRNME
MPALKKQRIDLRLTDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIDNPPEPNERLKR
AAKRLRNME
Download Length: 270 bp
>AT206780 NZ_CP077206:1679923-1680192 [Enterobacter bugandensis]
ATGCCAGCACTTAAAAAACAGCGTATCGATCTTCGCTTAACGGACGAAGACAAAACAATGATTGAAGAAGCGGCGGCGAT
GACGAATCAAACGATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGTGCTGCAGAGGTCATCGAGCAGCACCGTCGTC
TCGTGTTAAACGAAGCCTCCTGGAATGCGGTGATGGATGCTATCGACAATCCGCCAGAGCCAAATGAACGCCTCAAGCGA
GCGGCAAAACGTCTTCGAAACATGGAGTGA
ATGCCAGCACTTAAAAAACAGCGTATCGATCTTCGCTTAACGGACGAAGACAAAACAATGATTGAAGAAGCGGCGGCGAT
GACGAATCAAACGATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGTGCTGCAGAGGTCATCGAGCAGCACCGTCGTC
TCGTGTTAAACGAAGCCTCCTGGAATGCGGTGATGGATGCTATCGACAATCCGCCAGAGCCAAATGAACGCCTCAAGCGA
GCGGCAAAACGTCTTCGAAACATGGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|