Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 2639762..2640728 Replicon chromosome
Accession NC_003143
Organism Yersinia pestis CO92

Toxin (Protein)


Gene name - Uniprot ID A0A0E8XJV6
Locus tag YPO_RS12725 Protein ID WP_002210981.1
Coordinates 2640270..2640728 (+) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q66A69
Locus tag YPO_RS12720 Protein ID WP_002210982.1
Coordinates 2639762..2640208 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YPO_RS12700 2635352..2636326 - 975 WP_002210985.1 L-Ala-D/L-Glu epimerase -
YPO_RS12705 2636489..2636992 + 504 WP_002210984.1 thiol peroxidase -
YPO_RS12710 2637245..2637703 + 459 WP_002213775.1 IS200/IS605-like element IS1541B family transposase -
YPO_RS12715 2637850..2639427 - 1578 WP_002210983.1 transcriptional regulator TyrR -
YPO_RS12720 2639762..2640208 + 447 WP_002210982.1 DUF2384 domain-containing protein Antitoxin
YPO_RS12725 2640270..2640728 + 459 WP_002210981.1 RES family NAD+ phosphorylase Toxin
YPO_RS12730 2640738..2641799 - 1062 WP_002210980.1 YcjF family protein -
YPO_RS12735 2641796..2643193 - 1398 WP_002210979.1 YcjX family protein -
YPO_RS12740 2643174..2643416 - 243 WP_002216375.1 phage shock protein PspD -
YPO_RS12745 2643501..2643860 - 360 WP_002210977.1 envelope stress response membrane protein PspC -
YPO_RS12750 2643860..2644087 - 228 WP_002210976.1 envelope stress response membrane protein PspB -
YPO_RS12755 2644249..2644914 - 666 WP_002210975.1 phage shock protein PspA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2637245..2637703 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16994.38 Da        Isoelectric Point: 4.8732

>T20678 WP_002210981.1 NC_003143:2640270-2640728 [Yersinia pestis CO92]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Download         Length: 459 bp

>T20678 NC_003143:2640270-2640728 [Yersinia pestis CO92]
ATGACGCTATACCGCATTGTTATGCGCCGCTATCTTGCATCGGCATGGACTGGTTACGGCGCTGAAATCTATGGTGGTCG
TTGGAATCATAAAGGCCATGCTGCCATCTATTTAGCCAGCAGTATTTCATTGGCTATGCTCGAAACACTGGCACATATTC
AGGACAGTTCAACACTCAGCGAATTTGAATTATTCCAAATTGAAATCAGTGACAGCAGTATTATGTTGCTACAGCCGCAG
GACTGGCCCACGGATTGGCGTAGCGATCCGGCACCGGTGGCAACGATGGATGTCGGCACCGAGTGGCTGGAATCAGAATC
CTCGGTAGGCTTACTGGTCCCGTCCACGTTGGTGCCGTCAGAAAACAACCTACTGGTCAATCCTCATCACAAAGATTTTC
CAGCGTGTTTGGCCAGCGTCAAACCGCTCTCTTTTGTCTTTGATCCACGGTTAAAATAG

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16401.94 Da        Isoelectric Point: 9.7155

>AT20678 WP_002210982.1 NC_003143:2639762-2640208 [Yersinia pestis CO92]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Download         Length: 447 bp

>AT20678 NC_003143:2639762-2640208 [Yersinia pestis CO92]
ATGAGAGCGTACCGCCCAAACCCCGCGACTAAAATGGGAACGCTTTGGCGTGAAATTGGCTTACCCGCCAGCCGCGGCAC
GATATTGGTCGATAGTATCAAAATGGGGTTTTCTGTTGATGTTATCGACAGCATTCATTTATGGGCATCCATGCCTAAAG
CTGAAATATTACGTGCTACCGGTATCCCCAGCCGTAGCCTGACTCGCCGCCGCACACATGATGGCCGTTTTACGCCTGAA
GAAAGCGAGAGAATCGCACGTTTTGTCCGCGTAATGGATGCCGCTGTCGATTTGTTCGGCGGCGATAAAGGTAAAGCCAT
TACCTGGATGTCCACGCCCATCAAAGGATTGGGGTACCGCAGCCCAGACTCCTTACTGGAAACCGAAACTGGCGCACTGG
AAGTGTGTGATTTGATTGGTCGTTTGGAACACGGCGTCTTTACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E8XJV6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XFL1

References