206774

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc(toxin)
Location 627105..627676 Replicon chromosome
Accession NZ_CP077198
Organism Vibrio cholerae strain PS-4

Toxin (Protein)


Gene name doc Uniprot ID Q9KMA2
Locus tag KTC41_RS15910 Protein ID WP_000351248.1
Coordinates 627275..627676 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q8GNG3
Locus tag KTC41_RS15905 Protein ID WP_001080654.1
Coordinates 627105..627275 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTC41_RS15870 (KTC41_15880) 622239..622709 - 471 WP_000784954.1 RES family NAD+ phosphorylase -
KTC41_RS15875 (KTC41_15885) 622709..623161 - 453 WP_000024294.1 DUF2384 domain-containing protein -
KTC41_RS15880 (KTC41_15890) 623438..624909 + 1472 WP_258873552.1 IS3 family transposase -
KTC41_RS15885 (KTC41_15895) 625086..625367 + 282 WP_220285356.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
KTC41_RS15890 (KTC41_15900) 625364..625651 + 288 WP_162811448.1 type II toxin-antitoxin system RelE/ParE family toxin -
KTC41_RS15895 (KTC41_15905) 625856..626164 + 309 WP_001062214.1 transposase -
KTC41_RS15900 (KTC41_15910) 626161..627012 + 852 WP_220285310.1 IS3 family transposase -
KTC41_RS15905 (KTC41_15915) 627105..627275 + 171 WP_001080654.1 hypothetical protein Antitoxin
KTC41_RS15910 (KTC41_15920) 627275..627676 + 402 WP_000351248.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
KTC41_RS15915 (KTC41_15925) 627760..627879 + 120 Protein_672 nitrate reductase -
KTC41_RS15920 (KTC41_15930) 628338..629459 - 1122 Protein_673 IS3 family transposase -
KTC41_RS15925 (KTC41_15935) 629797..630444 + 648 WP_258873449.1 GyrI-like domain-containing protein -
KTC41_RS15930 (KTC41_15940) 630625..631611 - 987 WP_220285357.1 sulfate ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 505519..626164 120645
- inside Prophage - - 614958..641745 26787


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(1-132)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14608.71 Da        Isoelectric Point: 4.0128

>T206774 WP_000351248.1 NZ_CP077198:627275-627676 [Vibrio cholerae]
MDIICFPFERVIEINAFILKTEPGMKGAVDIPKLQGALGRIDNAIVYEGLDDVFEIAAKYTACIAVSHALPDANKRTGLA
VALEYLSLNDFELTQENDLLADAVRDLVIGIINETDFADILYAQYAKEQNSAL

Download         Length: 402 bp

>T206774 NZ_CP102679:1616147-1616401 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6287.35 Da        Isoelectric Point: 10.7274

>AT206774 WP_001080654.1 NZ_CP077198:627105-627275 [Vibrio cholerae]
MNRKVEAYGVDAVERPKIKASKKLDLTGDAGRQIVKSETKLALRTHQKTFTKLADM

Download         Length: 171 bp

>AT206774 NZ_CP102679:1615899-1616150 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0PN34

Antitoxin

Source ID Structure
AlphaFold DB A0A1T4SJJ1

References