Detailed information of TA system TA206773

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 625086..625651
• Replicon: chromosome
• Accession: NZ_CP077198
• Organism: Vibrio cholerae strain PS-4

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KTC41_RS15890
• Protein ID: WP_162811448.1
• Coordinates: 625364..625651 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: KTC41_RS15885
• Protein ID: WP_220285356.1
• Coordinates: 625086..625367 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTC41_RS15855 (KTC41_15865)	620799..621005	+	207	WP_248452457.1	GNAT family N-acetyltransferase	-
KTC41_RS17890	621062..621238	+	177	WP_258873448.1	acetyltransferase	-
KTC41_RS17895	621371..621426	+	56	Protein_660	DUF645 family protein	-
KTC41_RS17900	621405..621500	+	96	WP_230965109.1	Tfp pilus assembly protein	-
KTC41_RS15865 (KTC41_15875)	621740..622087	+	348	WP_220285355.1	DUF3024 domain-containing protein	-
KTC41_RS15870 (KTC41_15880)	622239..622709	-	471	WP_000784954.1	RES family NAD+ phosphorylase	-
KTC41_RS15875 (KTC41_15885)	622709..623161	-	453	WP_000024294.1	DUF2384 domain-containing protein	-
KTC41_RS15880 (KTC41_15890)	623438..624909	+	1472	WP_258873552.1	IS3 family transposase	-
KTC41_RS15885 (KTC41_15895)	625086..625367	+	282	WP_220285356.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KTC41_RS15890 (KTC41_15900)	625364..625651	+	288	WP_162811448.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KTC41_RS15895 (KTC41_15905)	625856..626164	+	309	WP_001062214.1	transposase	-
KTC41_RS15900 (KTC41_15910)	626161..627012	+	852	WP_220285310.1	IS3 family transposase	-
KTC41_RS15905 (KTC41_15915)	627105..627275	+	171	WP_001080654.1	hypothetical protein	-
KTC41_RS15910 (KTC41_15920)	627275..627676	+	402	WP_000351248.1	type II toxin-antitoxin system death-on-curing family toxin	-
KTC41_RS15915 (KTC41_15925)	627760..627879	+	120	Protein_672	nitrate reductase	-
KTC41_RS15920 (KTC41_15930)	628338..629459	-	1122	Protein_673	IS3 family transposase	-
KTC41_RS15925 (KTC41_15935)	629797..630444	+	648	WP_258873449.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	505519..626164	120645
	-	inside	Prophage	-	-	614958..641745	26787

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-74)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11055.78 Da
• Isoelectric Point: 5.5571

>T206773 WP_162811448.1 NZ_CP077198:625364-625651 [Vibrio cholerae]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFDHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV

Nucleotide

• Length: 288 bp

>T206773 NZ_CP102679:1615899-1616150 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10377.93 Da
• Isoelectric Point: 5.1548

>AT206773 WP_220285356.1 NZ_CP077198:625086-625367 [Vibrio cholerae]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYESMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK

Nucleotide

• Length: 282 bp

>AT206773 NZ_CP102679:1616147-1616401 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA