Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 613002..613540 | Replicon | chromosome |
| Accession | NZ_CP077198 | ||
| Organism | Vibrio cholerae strain PS-4 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | KTC41_RS15800 | Protein ID | WP_000802134.1 |
| Coordinates | 613002..613301 (-) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P58093 |
| Locus tag | KTC41_RS15805 | Protein ID | WP_001107719.1 |
| Coordinates | 613298..613540 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KTC41_RS15760 (KTC41_15770) | 608354..609226 | + | 873 | WP_084981861.1 | hypothetical protein | - |
| KTC41_RS17860 | 609337..609480 | + | 144 | WP_142741576.1 | acetyltransferase | - |
| KTC41_RS17865 | 609541..609694 | + | 154 | Protein_636 | DUF645 family protein | - |
| KTC41_RS17870 | 609811..610004 | + | 194 | Protein_637 | hypothetical protein | - |
| KTC41_RS15770 (KTC41_15780) | 610001..610225 | + | 225 | WP_220285823.1 | DUF3709 domain-containing protein | - |
| KTC41_RS15775 (KTC41_15785) | 610485..610775 | - | 291 | WP_000221352.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KTC41_RS15780 (KTC41_15790) | 610765..611013 | - | 249 | WP_000213183.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| KTC41_RS15785 (KTC41_15795) | 611371..611550 | + | 180 | WP_094392958.1 | DUF645 family protein | - |
| KTC41_RS15790 (KTC41_15800) | 611767..612348 | + | 582 | WP_220285350.1 | HD domain-containing protein | - |
| KTC41_RS15795 (KTC41_15805) | 612532..612768 | - | 237 | WP_000772130.1 | RNA-binding protein | - |
| KTC41_RS15800 (KTC41_15810) | 613002..613301 | - | 300 | WP_000802134.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KTC41_RS15805 (KTC41_15815) | 613298..613540 | - | 243 | WP_001107719.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| KTC41_RS15810 (KTC41_15820) | 613905..614058 | + | 154 | Protein_646 | DUF645 family protein | - |
| KTC41_RS15815 (KTC41_15825) | 614391..614595 | + | 205 | Protein_647 | DUF3709 domain-containing protein | - |
| KTC41_RS17875 | 614794..614901 | + | 108 | WP_258873444.1 | C4-dicarboxylate ABC transporter | - |
| KTC41_RS15820 (KTC41_15830) | 614958..615383 | + | 426 | WP_220285351.1 | hypothetical protein | - |
| KTC41_RS15825 (KTC41_15835) | 615667..615903 | + | 237 | WP_217519997.1 | DUF3709 domain-containing protein | - |
| KTC41_RS15830 (KTC41_15840) | 616175..616771 | + | 597 | WP_220285352.1 | hypothetical protein | - |
| KTC41_RS15835 (KTC41_15845) | 617113..617218 | + | 106 | Protein_652 | DUF645 family protein | - |
| KTC41_RS17880 | 617334..617510 | + | 177 | WP_258873447.1 | acetyltransferase | - |
| KTC41_RS15840 (KTC41_15850) | 617554..617652 | + | 99 | WP_254311288.1 | DUF645 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 505519..626164 | 120645 | |
| - | inside | Prophage | - | - | 614958..641745 | 26787 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11601.34 Da Isoelectric Point: 9.9232
>T206772 WP_000802134.1 NZ_CP077198:c613301-613002 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQIGSQQ
IRVIRILHKSMDVNPIFGA
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQIGSQQ
IRVIRILHKSMDVNPIFGA
Download Length: 300 bp
>T206772 NZ_CP102679:1063339-1063737 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8964.84 Da Isoelectric Point: 4.1677
>AT206772 WP_001107719.1 NZ_CP077198:c613540-613298 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR
Download Length: 243 bp
>AT206772 NZ_CP102679:1063112-1063339 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|