206771

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 610485..611013 Replicon chromosome
Accession NZ_CP077198
Organism Vibrio cholerae strain PS-4

Toxin (Protein)


Gene name relE Uniprot ID H9L4R3
Locus tag KTC41_RS15775 Protein ID WP_000221352.1
Coordinates 610485..610775 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID H9L4T4
Locus tag KTC41_RS15780 Protein ID WP_000213183.1
Coordinates 610765..611013 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTC41_RS17840 605882..605944 + 63 Protein_627 acetyltransferase -
KTC41_RS15730 (KTC41_15740) 605944..606249 + 306 WP_258873437.1 hypothetical protein -
KTC41_RS15735 (KTC41_15745) 606447..606689 + 243 WP_220285347.1 hypothetical protein -
KTC41_RS17845 607008..607097 + 90 WP_001905720.1 DUF645 family protein -
KTC41_RS17850 607133..607189 + 57 WP_088129470.1 DUF645 family protein -
KTC41_RS15745 (KTC41_15755) 607449..607691 + 243 WP_220285348.1 hypothetical protein -
KTC41_RS17855 607806..607949 + 144 WP_002051087.1 hypothetical protein -
KTC41_RS15760 (KTC41_15770) 608354..609226 + 873 WP_084981861.1 hypothetical protein -
KTC41_RS17860 609337..609480 + 144 WP_142741576.1 acetyltransferase -
KTC41_RS17865 609541..609694 + 154 Protein_636 DUF645 family protein -
KTC41_RS17870 609811..610004 + 194 Protein_637 hypothetical protein -
KTC41_RS15770 (KTC41_15780) 610001..610225 + 225 WP_220285823.1 DUF3709 domain-containing protein -
KTC41_RS15775 (KTC41_15785) 610485..610775 - 291 WP_000221352.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KTC41_RS15780 (KTC41_15790) 610765..611013 - 249 WP_000213183.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KTC41_RS15785 (KTC41_15795) 611371..611550 + 180 WP_094392958.1 DUF645 family protein -
KTC41_RS15790 (KTC41_15800) 611767..612348 + 582 WP_220285350.1 HD domain-containing protein -
KTC41_RS15795 (KTC41_15805) 612532..612768 - 237 WP_000772130.1 RNA-binding protein -
KTC41_RS15800 (KTC41_15810) 613002..613301 - 300 WP_000802134.1 type II toxin-antitoxin system RelE/ParE family toxin -
KTC41_RS15805 (KTC41_15815) 613298..613540 - 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin -
KTC41_RS15810 (KTC41_15820) 613905..614058 + 154 Protein_646 DUF645 family protein -
KTC41_RS15815 (KTC41_15825) 614391..614595 + 205 Protein_647 DUF3709 domain-containing protein -
KTC41_RS17875 614794..614901 + 108 WP_258873444.1 C4-dicarboxylate ABC transporter -
KTC41_RS15820 (KTC41_15830) 614958..615383 + 426 WP_220285351.1 hypothetical protein -
KTC41_RS15825 (KTC41_15835) 615667..615903 + 237 WP_217519997.1 DUF3709 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 505519..626164 120645
- inside Prophage - - 614958..641745 26787


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11247.23 Da        Isoelectric Point: 10.4678

>T206771 WP_000221352.1 NZ_CP077198:c610775-610485 [Vibrio cholerae]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Download         Length: 291 bp

>T206771 NZ_CP102679:776148-776483 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8937.28 Da        Isoelectric Point: 4.1079

>AT206771 WP_000213183.1 NZ_CP077198:c611013-610765 [Vibrio cholerae]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Download         Length: 249 bp

>AT206771 NZ_CP102679:775900-776148 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB H9L4R3

Antitoxin

Source ID Structure
AlphaFold DB A0A366A3W8

References