Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-Phd |
| Location | 590253..590800 | Replicon | chromosome |
| Accession | NZ_CP077198 | ||
| Organism | Vibrio cholerae strain PS-4 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A0Q0PYS1 |
| Locus tag | KTC41_RS15615 | Protein ID | WP_000229322.1 |
| Coordinates | 590498..590800 (+) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9KM93 |
| Locus tag | KTC41_RS15610 | Protein ID | WP_000861987.1 |
| Coordinates | 590253..590510 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KTC41_RS15575 (KTC41_15585) | 585539..585817 | + | 279 | WP_114794427.1 | hypothetical protein | - |
| KTC41_RS17785 | 586113..586159 | + | 47 | Protein_589 | DUF645 domain-containing protein | - |
| KTC41_RS15580 (KTC41_15590) | 586141..586282 | + | 142 | Protein_590 | DUF645 family protein | - |
| KTC41_RS15585 (KTC41_15595) | 586334..587457 | + | 1124 | WP_220285333.1 | IS3 family transposase | - |
| KTC41_RS15590 (KTC41_15600) | 587763..588455 | + | 693 | WP_220285334.1 | hypothetical protein | - |
| KTC41_RS17790 | 588526..588717 | + | 192 | WP_123013899.1 | disulfide bond formation protein DsbD | - |
| KTC41_RS15595 (KTC41_15605) | 589069..589305 | + | 237 | WP_220285335.1 | DUF3709 domain-containing protein | - |
| KTC41_RS17795 | 589641..589700 | + | 60 | WP_114012514.1 | hypothetical protein | - |
| KTC41_RS15605 (KTC41_15615) | 589697..589930 | + | 234 | WP_081018745.1 | DUF3709 domain-containing protein | - |
| KTC41_RS15610 (KTC41_15620) | 590253..590510 | + | 258 | WP_000861987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| KTC41_RS15615 (KTC41_15625) | 590498..590800 | + | 303 | WP_000229322.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KTC41_RS15620 (KTC41_15630) | 590878..591096 | + | 219 | WP_220285336.1 | DUF3709 domain-containing protein | - |
| KTC41_RS17800 | 591108..591326 | + | 219 | Protein_600 | DUF3709 domain-containing protein | - |
| KTC41_RS15630 (KTC41_15640) | 591751..591932 | + | 182 | Protein_601 | DUF645 family protein | - |
| KTC41_RS15635 (KTC41_15645) | 592147..592641 | - | 495 | WP_081096064.1 | hypothetical protein | - |
| KTC41_RS15640 (KTC41_15650) | 592891..593700 | + | 810 | WP_220285337.1 | hypothetical protein | - |
| KTC41_RS15645 (KTC41_15655) | 594004..594186 | + | 183 | WP_001933694.1 | DUF645 family protein | - |
| KTC41_RS15650 (KTC41_15660) | 594363..594914 | - | 552 | WP_220285338.1 | TetR/AcrR family transcriptional regulator | - |
| KTC41_RS15655 (KTC41_15665) | 595009..595461 | + | 453 | WP_220285339.1 | HPP family protein | - |
| KTC41_RS17805 | 595536..595703 | + | 168 | WP_258873549.1 | acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 505519..626164 | 120645 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11737.67 Da Isoelectric Point: 5.1972
>T206770 WP_000229322.1 NZ_CP077198:590498-590800 [Vibrio cholerae]
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ
MVEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPPELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ
Download Length: 303 bp
>T206770 NZ_CP102679:639812-640219 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9647.15 Da Isoelectric Point: 7.3178
>AT206770 WP_000861987.1 NZ_CP077198:590253-590510 [Vibrio cholerae]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
Download Length: 258 bp
>AT206770 NZ_CP102679:639565-639831 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0Q0PYS1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1T4SLM9 |