Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 2064772..2065418 Replicon chromosome
Accession NC_003143
Organism Yersinia pestis CO92

Toxin (Protein)


Gene name hicA Uniprot ID A0A3G5L3F2
Locus tag YPO_RS10070 Protein ID WP_002214976.1
Coordinates 2065236..2065418 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0U1R391
Locus tag YPO_RS10065 Protein ID WP_002211129.1
Coordinates 2064772..2065191 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
YPO_RS10045 2059843..2060838 + 996 WP_002211125.1 substrate-binding domain-containing protein -
YPO_RS10050 2060904..2062481 + 1578 WP_002211126.1 sugar ABC transporter ATP-binding protein -
YPO_RS10055 2062484..2063506 + 1023 WP_002214974.1 ABC transporter permease -
YPO_RS10060 2063555..2064514 + 960 WP_002211128.1 sugar kinase -
YPO_RS10065 2064772..2065191 - 420 WP_002211129.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
YPO_RS10070 2065236..2065418 - 183 WP_002214976.1 type II toxin-antitoxin system HicA family toxin Toxin
YPO_RS10075 2065625..2066407 - 783 WP_002211130.1 flagellar type III secretion system protein FliR -
YPO_RS10080 2066410..2066679 - 270 WP_002211131.1 flagellar biosynthesis protein FliQ -
YPO_RS10085 2066785..2067525 - 741 WP_002220494.1 flagellar type III secretion system pore protein FliP -
YPO_RS10090 2067606..2068142 - 537 WP_002211133.1 flagellar biosynthetic protein FliO -
YPO_RS10095 2068142..2068558 - 417 WP_002211134.1 flagellar motor switch protein FliN -
YPO_RS10100 2068555..2069556 - 1002 WP_002211135.1 flagellar motor switch protein FliM -
YPO_RS10105 2069562..2070032 - 471 WP_002227961.1 flagellar basal body-associated protein FliL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-131)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6783.99 Da        Isoelectric Point: 10.8877

>T20677 WP_002214976.1 NC_003143:c2065418-2065236 [Yersinia pestis CO92]
VKSSELIKLLETNGWKLMRVKGSHHQFKHPDFAAVITVPHPKKDVKPGTLRQILKDANLS

Download         Length: 183 bp

>T20677 NC_003143:c2065418-2065236 [Yersinia pestis CO92]
GTGAAAAGTTCGGAGCTGATAAAACTGCTCGAAACAAATGGTTGGAAGTTGATGAGAGTTAAAGGCAGTCATCATCAATT
CAAACATCCTGATTTCGCGGCAGTCATAACAGTACCGCATCCCAAAAAGGATGTTAAACCGGGAACCCTCCGGCAAATTC
TGAAAGATGCAAACCTTAGTTAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15549.42 Da        Isoelectric Point: 4.7731

>AT20677 WP_002211129.1 NC_003143:c2065191-2064772 [Yersinia pestis CO92]
MAIYPAYVHVDNDGSASGYFPDVKGCIFAINAGEDLFAEASSALDAHFEALVSEGIEIPEAHDMPYHVYRNPCDYADGGQ
WYNVNIDMSKYDGKVERINVTLPHRLIHQIDTIVKVRPEYASRSNFLAEAARKELQKLA

Download         Length: 420 bp

>AT20677 NC_003143:c2065191-2064772 [Yersinia pestis CO92]
ATGGCTATCTATCCCGCCTATGTTCACGTTGATAATGATGGCTCGGCAAGCGGTTATTTCCCCGATGTCAAAGGCTGTAT
TTTTGCCATCAATGCCGGGGAGGATTTATTTGCAGAAGCATCAAGCGCCCTGGATGCACACTTTGAAGCTTTGGTGTCTG
AAGGTATCGAAATTCCTGAAGCTCATGACATGCCTTACCACGTTTACCGTAACCCATGCGATTACGCTGATGGCGGACAG
TGGTATAACGTGAATATTGATATGTCGAAATATGATGGAAAAGTTGAACGAATTAACGTCACTCTTCCGCACCGGCTGAT
TCATCAAATCGATACTATTGTTAAAGTGCGTCCCGAGTATGCCAGCCGAAGCAATTTTCTAGCCGAAGCAGCACGTAAAG
AATTACAGAAATTGGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G5L3F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1R391

References