206769

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /BrnT(toxin)
Location 567655..568153 Replicon chromosome
Accession NZ_CP077198
Organism Vibrio cholerae strain PS-4

Toxin (Protein)


Gene name - Uniprot ID Q9KMK7
Locus tag KTC41_RS15415 Protein ID WP_000589156.1
Coordinates 567655..567921 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9KMK6
Locus tag KTC41_RS15420 Protein ID WP_000643598.1
Coordinates 567908..568153 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KTC41_RS15380 (KTC41_15390) 562791..563075 - 285 WP_000381183.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
KTC41_RS15385 (KTC41_15395) 563279..563749 + 471 WP_220285327.1 GNAT family N-acetyltransferase -
KTC41_RS15390 (KTC41_15400) 563925..564161 - 237 WP_000772130.1 RNA-binding protein -
KTC41_RS15395 (KTC41_15405) 564415..565062 + 648 WP_238792642.1 hypothetical protein -
KTC41_RS17725 565119..565184 + 66 Protein_547 acetyltransferase -
KTC41_RS15400 (KTC41_15410) 565204..565869 + 666 WP_142732695.1 hypothetical protein -
KTC41_RS15405 (KTC41_15415) 566067..566555 + 489 WP_220285328.1 hypothetical protein -
KTC41_RS17730 566552..566663 + 112 Protein_550 DUF3265 domain-containing protein -
KTC41_RS17735 566653..566788 + 136 Protein_551 acetyltransferase -
KTC41_RS15410 (KTC41_15420) 566852..567031 + 180 WP_199352816.1 DUF645 family protein -
KTC41_RS15415 (KTC41_15425) 567655..567921 + 267 WP_000589156.1 BrnT family toxin Toxin
KTC41_RS15420 (KTC41_15430) 567908..568153 + 246 WP_000643598.1 hypothetical protein Antitoxin
KTC41_RS17740 568249..568393 + 145 Protein_555 acetyltransferase -
KTC41_RS15425 (KTC41_15435) 568437..568535 + 99 WP_141563322.1 DUF645 family protein -
KTC41_RS17745 568889..569041 + 153 Protein_557 DUF645 family protein -
KTC41_RS15435 (KTC41_15445) 569245..569700 + 456 WP_220285329.1 hypothetical protein -
KTC41_RS17750 569773..569949 + 177 WP_258873432.1 acetyltransferase -
KTC41_RS15445 (KTC41_15455) 570320..570682 + 363 WP_000391481.1 DUF6232 family protein -
KTC41_RS15450 (KTC41_15460) 570839..571159 + 321 WP_002053845.1 hypothetical protein -
KTC41_RS15455 (KTC41_15465) 571175..571291 + 117 WP_080308819.1 DUF3265 domain-containing protein -
KTC41_RS15460 (KTC41_15470) 571281..571433 + 153 WP_220285828.1 DUF3709 domain-containing protein -
KTC41_RS15465 (KTC41_15475) 571427..571687 + 261 WP_172779951.1 DUF3709 domain-containing protein -
KTC41_RS15470 (KTC41_15480) 572457..572882 + 426 WP_001973845.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 505519..626164 120645


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10092.34 Da        Isoelectric Point: 7.3171

>T206769 WP_000589156.1 NZ_CP077198:567655-567921 [Vibrio cholerae]
MIKFEFDENKSRSNLEKHGIDFHTAQGLWNDSDLIEIPANTSDEPRYLVVGLLNGKHWSGVITYRGTNIRIISVRRSRKA
EVSLYESA

Download         Length: 267 bp

>T206769 NZ_CP102679:c490955-490578 [Escherichia coli]
ATGAAAACATTACCTGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGTTGGACCAGCATTACGGCCTCACACTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGCGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCAGGATTC
AGCGCCTGTACCCGTTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCCCGCCGGGCAACCGGCCTGATGGCCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9478.77 Da        Isoelectric Point: 6.4832

>AT206769 WP_000643598.1 NZ_CP077198:567908-568153 [Vibrio cholerae]
MKAHEFDAKFESDDDDIVMDLDLSQAKRPMHKQKRVNVDFPAWMLESLDREASRIGVTRQSIIKIWLAERLESVSHHSSV
R

Download         Length: 246 bp

>AT206769 NZ_CP102679:c491376-491002 [Escherichia coli]
GTGTCAGACACTCTCCCCGGGACAACGCATCCCGACGATAACAACGACCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATATGGCTGTTTATCCGACACTGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A271VMP7

Antitoxin

Source ID Structure
AlphaFold DB A0A271VME2

References