Detailed information of TA system TA206768

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 562516..563075
• Replicon: chromosome
• Accession: NZ_CP077198
• Organism: Vibrio cholerae strain PS-4

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KTC41_RS15375
• Protein ID: WP_142541873.1
• Coordinates: 562516..562794 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9L991
• Locus tag: KTC41_RS15380
• Protein ID: WP_000381183.1
• Coordinates: 562791..563075 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTC41_RS15325 (KTC41_15335)	557540..557929	+	390	WP_186295662.1	VOC family protein	-
KTC41_RS15330 (KTC41_15340)	558416..558793	+	378	WP_220285324.1	hypothetical protein	-
KTC41_RS17720	558858..558926	+	69	Protein_533	acetyltransferase	-
KTC41_RS15335 (KTC41_15345)	559094..559276	+	183	WP_033838039.1	DUF645 family protein	-
KTC41_RS15340 (KTC41_15350)	559480..559701	+	222	WP_088129314.1	hypothetical protein	-
KTC41_RS15345 (KTC41_15355)	559980..560258	+	279	WP_032469024.1	DUF3709 domain-containing protein	-
KTC41_RS15350 (KTC41_15360)	560575..560988	+	414	WP_000049418.1	VOC family protein	-
KTC41_RS15355 (KTC41_15365)	561117..561434	-	318	WP_000077453.1	CcdB family protein	-
KTC41_RS15360 (KTC41_15370)	561434..561679	-	246	WP_043990290.1	type II toxin-antitoxin system CcdA family antitoxin	-
KTC41_RS15365 (KTC41_15375)	561796..561990	+	195	WP_220285325.1	DUF3709 domain-containing protein	-
KTC41_RS15370 (KTC41_15380)	561984..562244	+	261	WP_258873546.1	DUF3709 domain-containing protein	-
KTC41_RS15375 (KTC41_15385)	562516..562794	-	279	WP_142541873.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KTC41_RS15380 (KTC41_15390)	562791..563075	-	285	WP_000381183.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KTC41_RS15385 (KTC41_15395)	563279..563749	+	471	WP_220285327.1	GNAT family N-acetyltransferase	-
KTC41_RS15390 (KTC41_15400)	563925..564161	-	237	WP_000772130.1	RNA-binding protein	-
KTC41_RS15395 (KTC41_15405)	564415..565062	+	648	WP_238792642.1	hypothetical protein	-
KTC41_RS17725	565119..565184	+	66	Protein_547	acetyltransferase	-
KTC41_RS15400 (KTC41_15410)	565204..565869	+	666	WP_142732695.1	hypothetical protein	-
KTC41_RS15405 (KTC41_15415)	566067..566555	+	489	WP_220285328.1	hypothetical protein	-
KTC41_RS17730	566552..566663	+	112	Protein_550	DUF3265 domain-containing protein	-
KTC41_RS17735	566653..566788	+	136	Protein_551	acetyltransferase	-
KTC41_RS15410 (KTC41_15420)	566852..567031	+	180	WP_199352816.1	DUF645 family protein	-
KTC41_RS15415 (KTC41_15425)	567655..567921	+	267	WP_000589156.1	BrnT family toxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	505519..626164	120645

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-70)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10868.59 Da
• Isoelectric Point: 4.6794

>T206768 WP_142541873.1 NZ_CP077198:c562794-562516 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPATAEKTDELIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Nucleotide

• Length: 279 bp

>T206768 NZ_CP102679:c362102-361719 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCAGGAGTCGAAACGATGCAACTGA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10901.25 Da
• Isoelectric Point: 8.0775

>AT206768 WP_000381183.1 NZ_CP077198:c563075-562791 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Nucleotide

• Length: 285 bp

>AT206768 NZ_CP102679:c362560-362192 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACGCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTACAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGTTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Structures

Antitoxin

• AlphaFold DB: A0A067BL33