Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /GNAT-DUF1778 |
| Location | 552107..552873 | Replicon | chromosome |
| Accession | NZ_CP077198 | ||
| Organism | Vibrio cholerae strain PS-4 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | Q9K2P7 |
| Locus tag | KTC41_RS15275 | Protein ID | WP_000982260.1 |
| Coordinates | 552107..552604 (-) | Length | 166 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0Q0PQR2 |
| Locus tag | KTC41_RS15280 | Protein ID | WP_000246255.1 |
| Coordinates | 552601..552873 (-) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KTC41_RS15235 (KTC41_15245) | 547174..547284 | + | 111 | WP_206212132.1 | acetyltransferase | - |
| KTC41_RS15240 (KTC41_15250) | 547260..547838 | + | 579 | WP_148518227.1 | DUF2726 domain-containing protein | - |
| KTC41_RS17685 | 548133..548285 | + | 153 | Protein_512 | DUF645 family protein | - |
| KTC41_RS15250 (KTC41_15260) | 548493..549047 | + | 555 | WP_162892118.1 | hypothetical protein | - |
| KTC41_RS15255 (KTC41_15265) | 549186..549500 | + | 315 | WP_267740189.1 | DUF4144 domain-containing protein | - |
| KTC41_RS15260 (KTC41_15270) | 549663..551429 | + | 1767 | WP_220285321.1 | P-loop NTPase fold protein | - |
| KTC41_RS17690 | 551752..551845 | + | 94 | Protein_516 | ggdef family protein | - |
| KTC41_RS17695 | 551814..551945 | + | 132 | WP_001883067.1 | hypothetical protein | - |
| KTC41_RS15275 (KTC41_15285) | 552107..552604 | - | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | Toxin |
| KTC41_RS15280 (KTC41_15290) | 552601..552873 | - | 273 | WP_000246255.1 | DUF1778 domain-containing protein | Antitoxin |
| KTC41_RS15285 (KTC41_15295) | 553114..553584 | + | 471 | WP_220285309.1 | GNAT family N-acetyltransferase | - |
| KTC41_RS15290 (KTC41_15300) | 553720..554037 | - | 318 | WP_220285319.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KTC41_RS15295 (KTC41_15305) | 554056..554298 | - | 243 | WP_000557291.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| KTC41_RS15300 (KTC41_15310) | 554614..554901 | + | 288 | WP_001162670.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KTC41_RS15305 (KTC41_15315) | 554912..555229 | + | 318 | WP_001232701.1 | HigA family addiction module antitoxin | - |
| KTC41_RS15310 (KTC41_15320) | 555866..556276 | + | 411 | WP_220285322.1 | hypothetical protein | - |
| KTC41_RS17700 | 556381..556524 | + | 144 | WP_080300930.1 | acetyltransferase | - |
| KTC41_RS17705 | 556657..556712 | + | 56 | Protein_527 | DUF645 family protein | - |
| KTC41_RS17710 | 556691..556786 | + | 96 | WP_230965109.1 | Tfp pilus assembly protein | - |
| KTC41_RS17715 | 556883..556997 | + | 115 | Protein_529 | acetyltransferase | - |
| KTC41_RS15320 (KTC41_15330) | 557006..557227 | + | 222 | WP_258873430.1 | DUF1289 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 505519..626164 | 120645 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 166 a.a. Molecular weight: 18527.18 Da Isoelectric Point: 8.7753
>T206765 WP_000982260.1 NZ_CP077198:c552604-552107 [Vibrio cholerae]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG
Download Length: 498 bp
>T206765 NZ_CP102678:7611-7865 [Escherichia coli]
ATGAGAAAAAACAAAGGGCGATTGACTTATTATCTTGAAGTGATTGATAAAAAATACCATTTTGTAAAAAAAATAAGCAG
TTATTCAAAGGAGTTCACTGACGGAAAAACAAAAAGAACAAAGAGAACGTTAAGTGAGCTGGTTTTTAATGAAAGTGAGG
TCGAGGCAATAGACTTTACAAAAAATGGTTTAAGACCTGTTGATAAGAATATTCTCTTAACTATGGTGAAAGAATATAAG
GAGAGTGATGCATGA
ATGAGAAAAAACAAAGGGCGATTGACTTATTATCTTGAAGTGATTGATAAAAAATACCATTTTGTAAAAAAAATAAGCAG
TTATTCAAAGGAGTTCACTGACGGAAAAACAAAAAGAACAAAGAGAACGTTAAGTGAGCTGGTTTTTAATGAAAGTGAGG
TCGAGGCAATAGACTTTACAAAAAATGGTTTAAGACCTGTTGATAAGAATATTCTCTTAACTATGGTGAAAGAATATAAG
GAGAGTGATGCATGA
Antitoxin
Download Length: 91 a.a. Molecular weight: 9713.24 Da Isoelectric Point: 6.2988
>AT206765 WP_000246255.1 NZ_CP077198:c552873-552601 [Vibrio cholerae]
MATTLPRITARVDVDTQDLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ
MATTLPRITARVDVDTQDLLTKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ
Download Length: 273 bp
>AT206765 NZ_CP102678:7862-8104 [Escherichia coli]
ATGACTATTGAAAATACACCGGAAAACATAAAGAAATTACGAAAAAAAATTGGCCTTACCCAGACAGAGTGCGGTGAGAT
TTTTGGCGTAGGCTTAAGTACATGGCAGAAAAAAGAAGCTAAAACCCACAACCAGCTTAATTTATCGAAAGGTGAATTTG
AGTACCTGTTATTACTTGCAGGGGAGCACCCTGAATACGTCCTGCATAAAAAAGCTGAATCCCGCTCACCGGAGGAACCG
TGA
ATGACTATTGAAAATACACCGGAAAACATAAAGAAATTACGAAAAAAAATTGGCCTTACCCAGACAGAGTGCGGTGAGAT
TTTTGGCGTAGGCTTAAGTACATGGCAGAAAAAAGAAGCTAAAACCCACAACCAGCTTAATTTATCGAAAGGTGAATTTG
AGTACCTGTTATTACTTGCAGGGGAGCACCCTGAATACGTCCTGCATAAAAAAGCTGAATCCCGCTCACCGGAGGAACCG
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0Q0KGB1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0Q0PQR2 |