Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-Phd |
| Location | 545358..545936 | Replicon | chromosome |
| Accession | NZ_CP077198 | ||
| Organism | Vibrio cholerae strain PS-4 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | KTC41_RS15215 | Protein ID | WP_220285319.1 |
| Coordinates | 545358..545675 (-) | Length | 106 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A366AI09 |
| Locus tag | KTC41_RS15220 | Protein ID | WP_000557291.1 |
| Coordinates | 545694..545936 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KTC41_RS15175 (KTC41_15185) | 540708..541202 | + | 495 | WP_095465420.1 | GNAT family N-acetyltransferase | - |
| KTC41_RS15180 (KTC41_15190) | 541320..541619 | - | 300 | WP_000802136.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KTC41_RS15185 (KTC41_15195) | 541616..541858 | - | 243 | WP_001107719.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| KTC41_RS15190 (KTC41_15200) | 542200..542436 | + | 237 | Protein_501 | DUF3709 domain-containing protein | - |
| KTC41_RS15195 (KTC41_15205) | 542728..543141 | + | 414 | WP_032482400.1 | GNAT family N-acetyltransferase | - |
| KTC41_RS15200 (KTC41_15210) | 543318..544082 | + | 765 | WP_142578249.1 | ATP-binding protein | - |
| KTC41_RS17680 | 544229..544420 | + | 192 | WP_258873425.1 | DUF3709 domain-containing protein | - |
| KTC41_RS15210 (KTC41_15220) | 544690..545223 | + | 534 | WP_000639076.1 | hypothetical protein | - |
| KTC41_RS15215 (KTC41_15225) | 545358..545675 | - | 318 | WP_220285319.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KTC41_RS15220 (KTC41_15230) | 545694..545936 | - | 243 | WP_000557291.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| KTC41_RS15225 (KTC41_15235) | 546187..546564 | + | 378 | WP_220285320.1 | hypothetical protein | - |
| KTC41_RS15230 (KTC41_15240) | 546743..547105 | + | 363 | WP_000391481.1 | DUF6232 family protein | - |
| KTC41_RS15235 (KTC41_15245) | 547174..547284 | + | 111 | WP_206212132.1 | acetyltransferase | - |
| KTC41_RS15240 (KTC41_15250) | 547260..547838 | + | 579 | WP_148518227.1 | DUF2726 domain-containing protein | - |
| KTC41_RS17685 | 548133..548285 | + | 153 | Protein_512 | DUF645 family protein | - |
| KTC41_RS15250 (KTC41_15260) | 548493..549047 | + | 555 | WP_162892118.1 | hypothetical protein | - |
| KTC41_RS15255 (KTC41_15265) | 549186..549500 | + | 315 | WP_267740189.1 | DUF4144 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 505519..626164 | 120645 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12169.95 Da Isoelectric Point: 9.2531
>T206764 WP_220285319.1 NZ_CP077198:c545675-545358 [Vibrio cholerae]
MQDKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAD
FILIVAVLGQSQLPQKHLKHSRFVS
MQDKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAD
FILIVAVLGQSQLPQKHLKHSRFVS
Download Length: 318 bp
>T206764 NZ_CP102677:98237-98617 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTTTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCCGCGGAGTAG
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGCTATTTTTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCCGCGGAGTAG
Antitoxin
Download Length: 81 a.a. Molecular weight: 8931.22 Da Isoelectric Point: 5.6630
>AT206764 WP_000557291.1 NZ_CP077198:c545936-545694 [Vibrio cholerae]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGAAFLNTL
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGAAFLNTL
Download Length: 243 bp
>AT206764 NZ_CP102677:98016-98237 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAAGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|