Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 541320..541858 | Replicon | chromosome |
| Accession | NZ_CP077198 | ||
| Organism | Vibrio cholerae strain PS-4 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | Q9KMJ0 |
| Locus tag | KTC41_RS15180 | Protein ID | WP_000802136.1 |
| Coordinates | 541320..541619 (-) | Length | 100 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | P58093 |
| Locus tag | KTC41_RS15185 | Protein ID | WP_001107719.1 |
| Coordinates | 541616..541858 (-) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KTC41_RS17660 | 536445..536585 | + | 141 | WP_258873545.1 | DUF3265 domain-containing protein | - |
| KTC41_RS15140 (KTC41_15150) | 536769..536951 | + | 183 | WP_033838039.1 | DUF645 family protein | - |
| KTC41_RS17665 | 537290..537442 | + | 153 | Protein_491 | DUF645 family protein | - |
| KTC41_RS15150 (KTC41_15160) | 537655..538278 | + | 624 | WP_258873424.1 | DUF4145 domain-containing protein | - |
| KTC41_RS17670 | 538286..538399 | + | 114 | Protein_493 | DUF3265 domain-containing protein | - |
| KTC41_RS15155 (KTC41_15165) | 538537..538761 | + | 225 | WP_220285823.1 | DUF3709 domain-containing protein | - |
| KTC41_RS15160 (KTC41_15170) | 539091..539507 | + | 417 | WP_220285317.1 | hypothetical protein | - |
| KTC41_RS17675 | 539869..539928 | + | 60 | Protein_496 | DUF645 family protein | - |
| KTC41_RS15170 (KTC41_15180) | 540345..540527 | + | 183 | WP_172779194.1 | DUF645 family protein | - |
| KTC41_RS15175 (KTC41_15185) | 540708..541202 | + | 495 | WP_095465420.1 | GNAT family N-acetyltransferase | - |
| KTC41_RS15180 (KTC41_15190) | 541320..541619 | - | 300 | WP_000802136.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KTC41_RS15185 (KTC41_15195) | 541616..541858 | - | 243 | WP_001107719.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| KTC41_RS15190 (KTC41_15200) | 542200..542436 | + | 237 | Protein_501 | DUF3709 domain-containing protein | - |
| KTC41_RS15195 (KTC41_15205) | 542728..543141 | + | 414 | WP_032482400.1 | GNAT family N-acetyltransferase | - |
| KTC41_RS15200 (KTC41_15210) | 543318..544082 | + | 765 | WP_142578249.1 | ATP-binding protein | - |
| KTC41_RS17680 | 544229..544420 | + | 192 | WP_258873425.1 | DUF3709 domain-containing protein | - |
| KTC41_RS15210 (KTC41_15220) | 544690..545223 | + | 534 | WP_000639076.1 | hypothetical protein | - |
| KTC41_RS15215 (KTC41_15225) | 545358..545675 | - | 318 | WP_220285319.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| KTC41_RS15220 (KTC41_15230) | 545694..545936 | - | 243 | WP_000557291.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| KTC41_RS15225 (KTC41_15235) | 546187..546564 | + | 378 | WP_220285320.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 505519..626164 | 120645 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 100 a.a. Molecular weight: 11589.29 Da Isoelectric Point: 9.9232
>T206763 WP_000802136.1 NZ_CP077198:c541619-541320 [Vibrio cholerae]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA
Download Length: 300 bp
>T206763 NZ_CP102676:131666-132064 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8964.84 Da Isoelectric Point: 4.1677
>AT206763 WP_001107719.1 NZ_CP077198:c541858-541616 [Vibrio cholerae]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR
Download Length: 243 bp
>AT206763 NZ_CP102676:131439-131666 [Escherichia coli]
ATGGAAACCACCGTATTTTTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAACGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA
ATGGAAACCACCGTATTTTTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAACGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|