Detailed information of TA system TA206762

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 528775..529334
• Replicon: chromosome
• Accession: NZ_CP077198
• Organism: Vibrio cholerae strain PS-4

Toxin (Protein)

• Gene name: relE
• Uniprot ID: D7HHK2
• Locus tag: KTC41_RS15080
• Protein ID: WP_000578471.1
• Coordinates: 528775..529053 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q9L991
• Locus tag: KTC41_RS15085
• Protein ID: WP_000381183.1
• Coordinates: 529050..529334 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KTC41_RS17625	523921..524088	+	168	WP_258873422.1	acetyltransferase	-
KTC41_RS17630	524221..524276	+	56	Protein_467	DUF645 family protein	-
KTC41_RS17635	524255..524350	+	96	WP_230965109.1	Tfp pilus assembly protein	-
KTC41_RS15055 (KTC41_15065)	524481..524642	+	162	Protein_469	DUF3709 domain-containing protein	-
KTC41_RS15060 (KTC41_15070)	524678..524830	+	153	WP_175242275.1	DUF3709 domain-containing protein	-
KTC41_RS15065 (KTC41_15075)	525575..526111	+	537	WP_114742726.1	cysteine hydrolase family protein	-
KTC41_RS15070 (KTC41_15080)	526650..527156	-	507	WP_071196504.1	hypothetical protein	-
KTC41_RS17640	527403..527660	+	258	WP_001893682.1	hypothetical protein	-
KTC41_RS15075 (KTC41_15085)	527988..528170	+	183	WP_000923151.1	DUF645 family protein	-
KTC41_RS15080 (KTC41_15090)	528775..529053	-	279	WP_000578471.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
KTC41_RS15085 (KTC41_15095)	529050..529334	-	285	WP_000381183.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
KTC41_RS15090 (KTC41_15100)	529563..529934	+	372	WP_240307929.1	hypothetical protein	-
KTC41_RS15095 (KTC41_15105)	530144..530665	+	522	WP_220285312.1	hypothetical protein	-
KTC41_RS15100 (KTC41_15110)	530666..531550	+	885	WP_220285313.1	DUF4868 domain-containing protein	-
KTC41_RS15105 (KTC41_15115)	531746..532090	+	345	WP_220285314.1	hypothetical protein	-
KTC41_RS17645	532177..532343	+	167	Protein_481	acetyltransferase	-
KTC41_RS17650	532404..532556	+	153	Protein_482	DUF645 family protein	-
KTC41_RS15115 (KTC41_15125)	532769..533323	+	555	WP_220285315.1	sugar O-acetyltransferase	-
KTC41_RS15120 (KTC41_15130)	533536..533844	+	309	WP_001062214.1	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	505519..626164	120645

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-70)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10838.56 Da
• Isoelectric Point: 4.6794

>T206762 WP_000578471.1 NZ_CP077198:c529053-528775 [Vibrio cholerae]
MIFWEEASLNDREKIFEFLYDFNPAAAEKTDELIEAKVENLLEQPLMGVQRDGIRGRLLIIPEISMIVSYWVDGSKIRIM
RVLHQKQKFPND

Nucleotide

• Length: 279 bp

>T206762 NZ_CP102676:c122710-122561 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10901.25 Da
• Isoelectric Point: 8.0775

>AT206762 WP_000381183.1 NZ_CP077198:c529334-529050 [Vibrio cholerae]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLAEQQRKALSHDAWLTEQVNQAFEKFDSGKAVFIEHDIAKAR
MAERKAKIRNRGHA

Nucleotide

• Length: 285 bp

>AT206762 NZ_CP102676:122754-122815 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Structures

Toxin

• AlphaFold DB: A0A271VKS2

Antitoxin

• AlphaFold DB: A0A067BL33