206755

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) TsdAT/-
Location 2258773..2259287 Replicon chromosome
Accession NZ_CP077098
Organism Staphylococcus aureus strain RGB-095930

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag KSF82_RS11480 Protein ID WP_000581792.1
Coordinates 2258773..2258982 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag KSF82_RS11485 Protein ID WP_000138932.1
Coordinates 2258994..2259287 (-) Length 98 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KSF82_RS11460 (2254281) 2254281..2255639 - 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
KSF82_RS11465 (2255654) 2255654..2256724 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
KSF82_RS11470 (2257042) 2257042..2258244 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
KSF82_RS11475 (2258508) 2258508..2258645 - 138 WP_000828354.1 Lmo0850 family protein -
KSF82_RS11480 (2258773) 2258773..2258982 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
KSF82_RS11485 (2258994) 2258994..2259287 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
KSF82_RS11490 (2259453) 2259453..2260937 + 1485 WP_000571549.1 cardiolipin synthase -
KSF82_RS11495 (2260965) 2260965..2261612 + 648 WP_001187629.1 HD domain-containing protein -
KSF82_RS11500 (2262425) 2262425..2263297 - 873 WP_000725802.1 membrane protein insertase YidC -
KSF82_RS11505 (2263383) 2263383..2264024 - 642 WP_070006250.1 thiamine phosphate synthase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T206755 WP_000581792.1 NZ_CP077098:c2258982-2258773 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T206755 NZ_CP102675:3734967-3735374 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT206755 WP_000138932.1 NZ_CP077098:c2259287-2258994 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT206755 NZ_CP102675:3734720-3734986 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6FF1


Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References