Detailed information of TA system TA206753

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2187715..2188247
• Replicon: chromosome
• Accession: NZ_CP077098
• Organism: Staphylococcus aureus strain RGB-095930

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: KSF82_RS11120
• Protein ID: WP_070974407.1
• Coordinates: 2187715..2188035 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: KSF82_RS11125
• Protein ID: WP_001058486.1
• Coordinates: 2188038..2188247 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KSF82_RS11095 (2182855)	2182855..2183196	-	342	WP_001190612.1	hypothetical protein	-
KSF82_RS11100 (2183720)	2183720..2184361	-	642	WP_070974405.1	pathogenicity island protein	-
KSF82_RS11105 (2184358)	2184358..2184738	-	381	WP_000356927.1	hypothetical protein	-
KSF82_RS11110 (2185068)	2185068..2186768	-	1701	WP_220668422.1	DUF927 domain-containing protein	-
KSF82_RS11115 (2186782)	2186782..2187651	-	870	WP_070974406.1	primase alpha helix C-terminal domain-containing protein	-
KSF82_RS11120 (2187715)	2187715..2188035	-	321	WP_070974407.1	DUF1474 family protein	Toxin
KSF82_RS11125 (2188038)	2188038..2188247	-	210	WP_001058486.1	hypothetical protein	Antitoxin
KSF82_RS11130 (2188240)	2188240..2188386	-	147	WP_000784885.1	hypothetical protein	-
KSF82_RS11135 (2188383)	2188383..2188700	-	318	WP_000481967.1	helix-turn-helix domain-containing protein	-
KSF82_RS11140 (2188705)	2188705..2188923	-	219	WP_000153640.1	helix-turn-helix transcriptional regulator	-
KSF82_RS11145 (2189096)	2189096..2189770	+	675	WP_000620857.1	helix-turn-helix transcriptional regulator	-
KSF82_RS11150 (2189784)	2189784..2190956	+	1173	WP_000179346.1	tyrosine-type recombinase/integrase	-
KSF82_RS11155 (2191025)	2191025..2192641	-	1617	WP_000240645.1	chaperonin GroEL	-
KSF82_RS11160 (2192717)	2192717..2193001	-	285	WP_000917289.1	co-chaperone GroES	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / sea / hlb / groEL	2122923..2195948	73025

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12725.19 Da
• Isoelectric Point: 4.5691

>T206753 WP_070974407.1 NZ_CP077098:c2188035-2187715 [Staphylococcus aureus]
MNWEIKDLMCDIEVVKEKINDVATKHAWFVEDRFVKNELETKREHINFSDSYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T206753 NZ_CP102675:c3457258-3456875 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCAGGAGTCGAAACGATGCAACTGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT206753 WP_001058486.1 NZ_CP077098:c2188247-2188038 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT206753 NZ_CP102675:c3457716-3457348 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACGCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTACAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGTTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA