Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 2052596..2053393 Replicon chromosome
Accession NZ_CP077098
Organism Staphylococcus aureus strain RGB-095930

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag KSF82_RS10260 Protein ID WP_089536026.1
Coordinates 2052932..2053393 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag KSF82_RS10255 Protein ID WP_045179171.1
Coordinates 2052596..2052919 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KSF82_RS10185 (2047612) 2047612..2047875 - 264 WP_001205732.1 hypothetical protein -
KSF82_RS10190 (2047884) 2047884..2048144 - 261 WP_089535939.1 DUF1108 family protein -
KSF82_RS10195 (2048210) 2048210..2048515 - 306 WP_089535940.1 helix-turn-helix transcriptional regulator -
KSF82_RS10200 (2048602) 2048602..2048922 - 321 WP_089535941.1 hypothetical protein -
KSF82_RS10205 (2048923) 2048923..2049090 - 168 WP_000048125.1 DUF1270 domain-containing protein -
KSF82_RS10210 (2049083) 2049083..2049304 - 222 WP_089535942.1 hypothetical protein -
KSF82_RS10215 (2049376) 2049376..2049978 + 603 WP_031877691.1 hypothetical protein -
KSF82_RS10220 (2049988) 2049988..2050112 - 125 Protein_1993 hypothetical protein -
KSF82_RS10225 (2050140) 2050140..2050451 - 312 WP_089535944.1 hypothetical protein -
KSF82_RS10230 (2050528) 2050528..2050755 + 228 WP_089535945.1 hypothetical protein -
KSF82_RS10235 (2050752) 2050752..2050919 - 168 WP_180895958.1 hypothetical protein -
KSF82_RS10240 (2050932) 2050932..2051726 - 795 WP_220668413.1 phage antirepressor KilAC domain-containing protein -
KSF82_RS10245 (2051985) 2051985..2052167 - 183 WP_046597466.1 hypothetical protein -
KSF82_RS10250 (2052183) 2052183..2052407 - 225 WP_259469722.1 helix-turn-helix transcriptional regulator -
KSF82_RS10255 (2052596) 2052596..2052919 + 324 WP_045179171.1 helix-turn-helix transcriptional regulator Antitoxin
KSF82_RS10260 (2052932) 2052932..2053393 + 462 WP_089536026.1 toxin Toxin
KSF82_RS10265 (2053409) 2053409..2053840 + 432 WP_089536027.1 hypothetical protein -
KSF82_RS10270 (2054134) 2054134..2055180 + 1047 WP_001145732.1 tyrosine-type recombinase/integrase -
KSF82_RS10275 (2055225) 2055225..2056370 + 1146 WP_220668414.1 radical SAM/CxCxxxxC motif protein YfkAB -
KSF82_RS10280 (2056630) 2056630..2057160 - 531 WP_000184383.1 acyl-CoA thioesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2014291..2055180 40889


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18067.52 Da        Isoelectric Point: 5.3089

>T206749 WP_089536026.1 NZ_CP077098:2052932-2053393 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEKYILEAINHYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T206749 NZ_CP102675:c2283022-2282849 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12489.13 Da        Isoelectric Point: 8.4338

>AT206749 WP_045179171.1 NZ_CP077098:2052596-2052919 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANELKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT206749 NZ_CP102675:c2283346-2283050 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References