Detailed information of TA system TA206748

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1983140..1983916
• Replicon: chromosome
• Accession: NZ_CP077098
• Organism: Staphylococcus aureus strain RGB-095930

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: KSF82_RS09680
• Protein ID: WP_000031108.1
• Coordinates: 1983140..1983292 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: KSF82_RS09685
• Protein ID: WP_001251224.1
• Coordinates: 1983317..1983916 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KSF82_RS09665 (1979103)	1979103..1979924	+	822	WP_000669376.1	RluA family pseudouridine synthase	-
KSF82_RS09670 (1980387)	1980387..1981772	-	1386	WP_000116224.1	class II fumarate hydratase	-
KSF82_RS09675 (1981968)	1981968..1982363	-	396	WP_000901021.1	hypothetical protein	-
KSF82_RS09680 (1983140)	1983140..1983292	-	153	WP_000031108.1	SAS053 family protein	Toxin
KSF82_RS09685 (1983317)	1983317..1983916	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
KSF82_RS09690 (1984075)	1984075..1984545	-	471	WP_000181398.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
KSF82_RS09695 (1984550)	1984550..1985677	-	1128	WP_000379978.1	tRNA epoxyqueuosine(34) reductase QueG	-
KSF82_RS09700 (1985828)	1985828..1986550	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
KSF82_RS09705 (1986543)	1986543..1988000	-	1458	WP_000649907.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T206748 WP_000031108.1 NZ_CP077098:c1983292-1983140 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T206748 NZ_CP102675:c2186734-2186384 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT206748 WP_001251224.1 NZ_CP077098:c1983916-1983317 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT206748 NZ_CP102675:c2186979-2186728 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4