Detailed information of TA system TA206745

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 867281..867813
• Replicon: chromosome
• Accession: NZ_CP077098
• Organism: Staphylococcus aureus strain RGB-095930

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q93CD4
• Locus tag: KSF82_RS04160
• Protein ID: WP_001103942.1
• Coordinates: 867493..867813 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: KSF82_RS04155
• Protein ID: WP_001058486.1
• Coordinates: 867281..867490 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KSF82_RS04110 (862300)	862300..863520	-	1221	WP_000266157.1	site-specific integrase	-
KSF82_RS04115 (863609)	863609..864337	-	729	WP_000733775.1	staphylococcal enterotoxin type K	-
KSF82_RS04120 (864361)	864361..865089	-	729	WP_001033316.1	staphylococcal enterotoxin type Q	-
KSF82_RS04125 (865159)	865159..865590	-	432	WP_001228759.1	hypothetical protein	-
KSF82_RS04130 (865607)	865607..866065	-	459	WP_000281657.1	ImmA/IrrE family metallo-endopeptidase	-
KSF82_RS04135 (866077)	866077..866409	-	333	WP_001260004.1	helix-turn-helix transcriptional regulator	-
KSF82_RS04140 (866602)	866602..866865	+	264	WP_000243850.1	helix-turn-helix transcriptional regulator	-
KSF82_RS04145 (866858)	866858..867130	+	273	WP_000091731.1	helix-turn-helix domain-containing protein	-
KSF82_RS04150 (867142)	867142..867288	+	147	WP_000784875.1	hypothetical protein	-
KSF82_RS04155 (867281)	867281..867490	+	210	WP_001058486.1	hypothetical protein	Antitoxin
KSF82_RS04160 (867493)	867493..867813	+	321	WP_001103942.1	DUF1474 family protein	Toxin
KSF82_RS04165 (867877)	867877..868746	+	870	WP_220668482.1	primase alpha helix C-terminal domain-containing protein	-
KSF82_RS04170 (868763)	868763..870220	+	1458	WP_000390455.1	virulence-associated E family protein	-
KSF82_RS04175 (870521)	870521..870883	+	363	WP_001039168.1	hypothetical protein	-
KSF82_RS04180 (870885)	870885..871169	+	285	WP_000998181.1	hypothetical protein	-
KSF82_RS04185 (871166)	871166..871807	+	642	WP_001019764.1	hypothetical protein	-
KSF82_RS04190 (872324)	872324..872665	+	342	WP_001190615.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / selq / seb	844351..877615	33264

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12694.22 Da
• Isoelectric Point: 4.7419

>T206745 WP_001103942.1 NZ_CP077098:867493-867813 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T206745 NZ_CP102675:1637431-1637709 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAAGTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT206745 WP_001058486.1 NZ_CP077098:867281-867490 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT206745 NZ_CP102675:1637168-1637428 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Structures

Toxin

• AlphaFold DB: Q93CD4