Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 849667..850144 Replicon chromosome
Accession NZ_CP077098
Organism Staphylococcus aureus strain RGB-095930

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag KSF82_RS04015 Protein ID WP_000052078.1
Coordinates 849667..849855 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag KSF82_RS04020 Protein ID WP_001059690.1
Coordinates 849884..850144 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KSF82_RS03985 (845708) 845708..846178 + 471 WP_000824472.1 hypothetical protein -
KSF82_RS03990 (846519) 846519..847205 + 687 WP_001548082.1 thermonuclease family protein -
KSF82_RS03995 (847562) 847562..847762 + 201 WP_001059082.1 cold-shock protein -
KSF82_RS04000 (848258) 848258..848476 - 219 WP_000005886.1 hypothetical protein -
KSF82_RS04005 (848538) 848538..848822 - 285 WP_001004395.1 hypothetical protein -
KSF82_RS04010 (848910) 848910..849479 - 570 WP_001106654.1 lipoprotein N-acylation protein LnsA -
KSF82_RS04015 (849667) 849667..849855 - 189 WP_000052078.1 hypothetical protein Toxin
KSF82_RS04020 (849884) 849884..850144 - 261 WP_001059690.1 hypothetical protein Antitoxin
KSF82_RS04025 (850485) 850485..850688 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
KSF82_RS04030 (850685) 850685..850921 - 237 WP_000368687.1 hypothetical protein -
KSF82_RS04035 (851146) 851146..851727 + 582 WP_001140686.1 histidine phosphatase family protein -
KSF82_RS04040 (851800) 851800..852417 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
KSF82_RS04045 (852572) 852572..853066 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
KSF82_RS04050 (853465) 853465..853887 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
KSF82_RS04055 (854035) 854035..854751 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq / seb 844351..877615 33264


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(19-96)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T206744 WP_000052078.1 NZ_CP077098:c849855-849667 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T206744 NZ_CP102675:1402264-1402806 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT206744 WP_001059690.1 NZ_CP077098:c850144-849884 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT206744 NZ_CP102675:1401969-1402280 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References