Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 3822918..3823527 Replicon chromosome
Accession NZ_CP077097
Organism Pseudomonas anuradhapurensis strain RD8MR3

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag HU763_RS17600 Protein ID WP_186688536.1
Coordinates 3822918..3823220 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag HU763_RS17605 Protein ID WP_186688533.1
Coordinates 3823213..3823527 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU763_RS24860 3818832..3818960 - 129 WP_009683677.1 PA1414 family protein -
HU763_RS17580 (HU763_017580) 3819085..3819978 - 894 WP_186688545.1 LysR family transcriptional regulator -
HU763_RS17585 (HU763_017585) 3820084..3821253 + 1170 WP_186688543.1 MFS transporter -
HU763_RS17590 (HU763_017590) 3821314..3822240 - 927 WP_186688541.1 DMT family transporter -
HU763_RS17595 (HU763_017595) 3822347..3822742 - 396 WP_186688539.1 transcriptional regulator -
HU763_RS17600 (HU763_017600) 3822918..3823220 + 303 WP_186688536.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HU763_RS17605 (HU763_017605) 3823213..3823527 + 315 WP_186688533.1 putative addiction module antidote protein Antitoxin
HU763_RS17610 (HU763_017610) 3823579..3823851 + 273 WP_186688530.1 hypothetical protein -
HU763_RS17615 (HU763_017615) 3824019..3825380 - 1362 WP_186688527.1 DEAD/DEAH box helicase -
HU763_RS17620 (HU763_017620) 3825484..3826785 + 1302 WP_186688524.1 mechanosensitive ion channel family protein -
HU763_RS17625 (HU763_017625) 3826820..3828208 - 1389 WP_186688521.1 cytosine permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3815100..3834751 19651


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(6-94)

Antitoxin

Uncharacterized protein HI1420

(8-97)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11378.01 Da        Isoelectric Point: 10.8773

>T206743 WP_186688536.1 NZ_CP077097:3822918-3823220 [Pseudomonas anuradhapurensis]
MKKIESSSFRHWVTGLRDVNARTRIISRINRLMEGLPGDVSPVGHGVSELRVHYGPGYRVYFHQAGSTFVILLCGGDKGS
QQRDIKTAHQILRSWRMQND

Download         Length: 303 bp

>T206743 NZ_CP102675:1368293-1368511 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11306.83 Da        Isoelectric Point: 6.2193

>AT206743 WP_186688533.1 NZ_CP077097:3823213-3823527 [Pseudomonas anuradhapurensis]
MTETFSEFDPAQYLTTPEAIAQFMTDALETGDAGYVAKAVGVVARAKGMSELAKETGLSREQLYRSFSEHGNPTLKSFLT
VMKALGIDMTAQPHLAGHRSRPLN

Download         Length: 315 bp

>AT206743 NZ_CP102675:1367893-1368267 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References