Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 2190435..2191318 Replicon chromosome
Accession NZ_CP077097
Organism Pseudomonas anuradhapurensis strain RD8MR3

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag HU763_RS10140 Protein ID WP_186684593.1
Coordinates 2190881..2191318 (+) Length 146 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag HU763_RS10135 Protein ID WP_186684591.1
Coordinates 2190435..2190884 (+) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU763_RS10110 (HU763_010110) 2185858..2187057 + 1200 WP_186684580.1 sugar transporter -
HU763_RS10115 (HU763_010115) 2187109..2187693 - 585 WP_186684582.1 LysE family transporter -
HU763_RS10120 (HU763_010120) 2187744..2188574 - 831 WP_186684584.1 AraC family transcriptional regulator -
HU763_RS10125 (HU763_010125) 2188624..2189547 - 924 WP_186684586.1 LysR family transcriptional regulator -
HU763_RS10130 (HU763_010130) 2189652..2190305 + 654 WP_186684588.1 oxygen-insensitive NAD(P)H nitroreductase -
HU763_RS10135 (HU763_010135) 2190435..2190884 + 450 WP_186684591.1 DUF2384 domain-containing protein Antitoxin
HU763_RS10140 (HU763_010140) 2190881..2191318 + 438 WP_186684593.1 RES family NAD+ phosphorylase Toxin
HU763_RS10145 (HU763_010145) 2191326..2192480 - 1155 WP_186684595.1 aminotransferase class V-fold PLP-dependent enzyme -
HU763_RS10150 (HU763_010150) 2192675..2193601 - 927 WP_170029332.1 LysR family transcriptional regulator -
HU763_RS10155 (HU763_010155) 2193742..2194965 + 1224 WP_186684598.1 acyl-CoA dehydrogenase -
HU763_RS10160 (HU763_010160) 2194962..2195771 - 810 WP_186685055.1 OBAP family protein -
HU763_RS10165 (HU763_010165) 2195926..2196294 + 369 WP_170029334.1 DNA binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-137)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(33-91)


Sequences

Toxin        


Download         Length: 146 a.a.        Molecular weight: 16059.36 Da        Isoelectric Point: 6.0718

>T206742 WP_186684593.1 NZ_CP077097:2190881-2191318 [Pseudomonas anuradhapurensis]
VILWRISAYADLSGTGGLRVSGRWHQAGRPVVYAATSPAGAMLEVLVHLEIDPEDFPTTMRLLRIELPDTVSQAQLPALQ
PGWSTQTELTRGLGNRFLDDCSALLLPVPSAIMPRTINYLFNPRHPQAHSARLDVEDFTPDSRLF

Download         Length: 438 bp

>T206742 NZ_CP102675:612043-612150 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 17002.62 Da        Isoelectric Point: 6.3398

>AT206742 WP_186684591.1 NZ_CP077097:2190435-2190884 [Pseudomonas anuradhapurensis]
MLAEVLRDNGYHEYRVRLHALLEIPELASDFEIHTRITHGFAATWLVKLTELGVFTPVERDQIIPLRTLKSRIERDQPLT
VEESDRLFRSAHITAMAEAVFGDAAKAKRWLSKPKERFAGLTPMQMLTTQQGTTQVEEMLLQIAEGFGL

Download         Length: 450 bp

>AT206742 NZ_CP102675:c611993-611930 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References