Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4933827..4934467 Replicon chromosome
Accession NZ_CP077095
Organism Pseudomonas xantholysinigenes strain RW9S1A

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HU772_RS22010 Protein ID WP_186660725.1
Coordinates 4934057..4934467 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HU772_RS22005 Protein ID WP_186660724.1
Coordinates 4933827..4934057 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU772_RS21985 (HU772_021985) 4929179..4930504 - 1326 WP_186660719.1 precorrin-3B synthase -
HU772_RS21990 (HU772_021990) 4930720..4931931 + 1212 WP_186660721.1 precorrin-6y C5,15-methyltransferase (decarboxylating) subunit CbiE -
HU772_RS21995 (HU772_021995) 4931924..4933018 + 1095 WP_186660722.1 cobalt-precorrin-5B (C(1))-methyltransferase -
HU772_RS22000 (HU772_022000) 4933015..4933743 + 729 WP_186660723.1 cobalt-precorrin-6A reductase -
HU772_RS22005 (HU772_022005) 4933827..4934057 + 231 WP_186660724.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HU772_RS22010 (HU772_022010) 4934057..4934467 + 411 WP_186660725.1 tRNA(fMet)-specific endonuclease VapC Toxin
HU772_RS22015 (HU772_022015) 4934541..4934978 + 438 WP_186660726.1 NfeD family protein -
HU772_RS22020 (HU772_022020) 4935006..4935860 + 855 WP_110735010.1 SPFH domain-containing protein -
HU772_RS22025 (HU772_022025) 4936046..4936435 + 390 WP_186660727.1 DUF2946 domain-containing protein -
HU772_RS22030 (HU772_022030) 4936483..4936965 + 483 WP_186660728.1 copper chaperone PCu(A)C -
HU772_RS22035 (HU772_022035) 4936990..4937421 + 432 WP_186660729.1 DUF2946 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15183.53 Da        Isoelectric Point: 9.4576

>T206740 WP_186660725.1 NZ_CP077095:4934057-4934467 [Pseudomonas xantholysinigenes]
MLRYMLDTNICIFTIKNKPQVVREAFNRYHGQLAISTVTLMELIYGAEKSAAPERNLAIVEGFAARLDVLDYDIQGAAHT
AQLRAELAKAGTPIGPYDRMIAGHARARGLTLVTSNLREFQRVPGLRVEDWVTSPR

Download         Length: 411 bp

>T206740 NZ_CP102675:610972-611079 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8457.39 Da        Isoelectric Point: 4.2958

>AT206740 WP_186660724.1 NZ_CP077095:4933827-4934057 [Pseudomonas xantholysinigenes]
MEQGAVFKSNRSQAIRMPKALALPEDVTRVDIVAVGRSRIISPAGESWDSWFEGEDVSADFMASREQPADQEREGF

Download         Length: 231 bp

>AT206740 NZ_CP102675:c610924-610857 [Escherichia coli]
GTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References