Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 311809..312431 Replicon chromosome
Accession NZ_CP077095
Organism Pseudomonas xantholysinigenes strain RW9S1A

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HU772_RS01405 Protein ID WP_134693260.1
Coordinates 311809..312000 (+) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HU772_RS01410 Protein ID WP_186653820.1
Coordinates 312018..312431 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU772_RS01380 (HU772_001380) 306939..308705 + 1767 WP_186653848.1 SUMF1/EgtB/PvdO family nonheme iron enzyme -
HU772_RS01385 (HU772_001385) 308784..309710 + 927 WP_186653836.1 type VI secretion system-associated lipoprotein TagQ -
HU772_RS01390 (HU772_001390) 309937..310794 + 858 WP_186654167.1 NAD synthetase -
HU772_RS01395 (HU772_001395) 310791..311210 + 420 WP_217858748.1 hypothetical protein -
HU772_RS01400 (HU772_001400) 311214..311648 + 435 WP_186653822.1 hypothetical protein -
HU772_RS01405 (HU772_001405) 311809..312000 + 192 WP_134693260.1 type II toxin-antitoxin system HicA family toxin Toxin
HU772_RS01410 (HU772_001410) 312018..312431 + 414 WP_186653820.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HU772_RS01415 (HU772_001415) 312432..313811 - 1380 WP_186653818.1 ATP-binding protein -
HU772_RS01420 (HU772_001420) 313813..314532 - 720 WP_186653815.1 response regulator transcription factor -
HU772_RS01425 (HU772_001425) 314674..316968 + 2295 WP_186653812.1 TonB-dependent siderophore receptor -
HU772_RS24895 316920..317177 - 258 WP_225923082.1 DUF3079 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7089.28 Da        Isoelectric Point: 10.1618

>T206736 WP_134693260.1 NZ_CP077095:311809-312000 [Pseudomonas xantholysinigenes]
MNSREMISVIEADGWYLVRCKGSHHHFKHPDKPGLVTIPHPKKDLLPATAASILRQARIVYAS

Download         Length: 192 bp

>T206736 NZ_CP102673:100263-100412 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 14899.01 Da        Isoelectric Point: 4.5918

>AT206736 WP_186653820.1 NZ_CP077095:312018-312431 [Pseudomonas xantholysinigenes]
MLFPIAILPGDDQYAWGVEVPDIPGCFSAGEDLDNAIAMAREAIEGHLELLAQDQQEIPKASKVAVHAANPAYAGCTWAL
IDIDITRYLGKAEKLNITLPAYLLTRIDSYVQNHPEHKSRSGFLAEAALKILQGEGK

Download         Length: 414 bp

>AT206736 NZ_CP102673:c100219-100158 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References