Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-DUF971
Location 4961161..4961759 Replicon chromosome
Accession NZ_CP077094
Organism Pseudomonas promysalinigenes strain RW10S1

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag HU725_RS22465 Protein ID WP_186476156.1
Coordinates 4961457..4961759 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag HU725_RS22460 Protein ID WP_060477254.1
Coordinates 4961161..4961460 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU725_RS22440 (HU725_022440) 4957064..4957432 - 369 WP_186476158.1 hypothetical protein -
HU725_RS22445 (HU725_022445) 4957608..4958297 + 690 WP_003253341.1 phosphate regulon transcriptional regulator PhoB -
HU725_RS22450 (HU725_022450) 4958346..4959653 + 1308 WP_186476157.1 phosphate regulon sensor histidine kinase PhoR -
HU725_RS22455 (HU725_022455) 4959781..4961121 + 1341 WP_060477253.1 hemolysin family protein -
HU725_RS22460 (HU725_022460) 4961161..4961460 - 300 WP_060477254.1 putative addiction module antidote protein Antitoxin
HU725_RS22465 (HU725_022465) 4961457..4961759 - 303 WP_186476156.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HU725_RS22470 (HU725_022470) 4961801..4962703 - 903 WP_186476155.1 M23 family metallopeptidase -
HU725_RS22475 (HU725_022475) 4962818..4963717 - 900 WP_060477257.1 response regulator -
HU725_RS22480 (HU725_022480) 4963882..4964652 - 771 WP_186476154.1 phosphate signaling complex protein PhoU -
HU725_RS22485 (HU725_022485) 4964807..4965640 - 834 WP_060477259.1 phosphate ABC transporter ATP-binding protein PstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-95)

Antitoxin

Uncharacterized protein HI1420

(6-93)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11351.89 Da        Isoelectric Point: 10.3124

>T206735 WP_186476156.1 NZ_CP077094:c4961759-4961457 [Pseudomonas promysalinigenes]
MKSIKQTATYRNWERKLRDKQARAIIAARVFRLAHGLLGDVQPVGQGISELRIHHGPGYRIYYQQRGNQLVLLLCGGDKS
SQSRDIETAKSLASQWSDDE

Download         Length: 303 bp

>T206735 NZ_CP102673:c91307-90909 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATAAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10832.27 Da        Isoelectric Point: 5.1133

>AT206735 WP_060477254.1 NZ_CP077094:c4961460-4961161 [Pseudomonas promysalinigenes]
MKEQFYDYDPAEALTDAESIAIFMEDAFETGDAAYIAQALGVVARAKGMTTIATEAGVSREHLYRSFSEKGNPTLKTMLA
VMRAVGLDLTSRRHSKPAQ

Download         Length: 300 bp

>AT206735 NZ_CP102673:c91534-91307 [Escherichia coli]
ATGGAAACCACCGTATTTTTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCAGAATCATTACGCCAGCCGGAGAGACATGGGACGAATGGTTCGACGGAC
ACAACGTCAGCGCCGATTTTATGGATAACAGGGAACAGCCCGGCATGCAGGAAAGGGAGTCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References