206733

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4424979..4425613 Replicon chromosome
Accession NZ_CP077093
Organism Pseudomonas vanderleydeniana strain RW8P3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag HU752_RS19710 Protein ID WP_186679050.1
Coordinates 4424979..4425383 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag HU752_RS19715 Protein ID WP_186679048.1
Coordinates 4425383..4425613 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU752_RS19690 (HU752_019690) 4420517..4421320 + 804 WP_186679577.1 4-hydroxy-2-oxoheptanedioate aldolase -
HU752_RS19695 (HU752_019695) 4421367..4422098 - 732 WP_186679055.1 GntR family transcriptional regulator -
HU752_RS19700 (HU752_019700) 4422217..4423572 + 1356 WP_186679053.1 adenylosuccinate lyase family protein -
HU752_RS19705 (HU752_019705) 4423641..4424942 + 1302 WP_186679052.1 cation:dicarboxylase symporter family transporter -
HU752_RS19710 (HU752_019710) 4424979..4425383 - 405 WP_186679050.1 tRNA(fMet)-specific endonuclease VapC Toxin
HU752_RS19715 (HU752_019715) 4425383..4425613 - 231 WP_186679048.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HU752_RS19720 (HU752_019720) 4425825..4425995 + 171 WP_186679046.1 CrpP family ICE-associated protein -
HU752_RS19725 (HU752_019725) 4426155..4427624 - 1470 WP_186679042.1 hypothetical protein -
HU752_RS19730 (HU752_019730) 4427788..4428012 - 225 WP_186679039.1 hypothetical protein -
HU752_RS19735 (HU752_019735) 4428190..4428939 + 750 WP_186679036.1 ABC transporter substrate-binding protein -
HU752_RS19740 (HU752_019740) 4429054..4430277 + 1224 WP_186679033.1 DUF1444 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4331995..4703579 371584


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15024.14 Da        Isoelectric Point: 7.3222

>T206733 WP_186679050.1 NZ_CP077093:c4425383-4424979 [Pseudomonas vanderleydeniana]
MLKFMLDTNMCIFTIKNRPEQVREAFKRHHGQMCISTVTLMELIYGAEKSSNPERNLADVEGFAARLDVLAYDQSAAAHT
GQVRAELARAGQPIGPYDYMIAGHARSQGLIVVTNNRREFDRVPGLRVEDWAAS

Download         Length: 405 bp

>T206733 NZ_CP102672:c33442-33194 [Escherichia coli]
ATGGGGAAAGCAGATAAGCTACTGGCAAAATTTTTAAACAGTAAAAAAACGTTTGAATGGGATGAACTCGTTGTTTTGTT
TTCTTCTCTAGGATATGTCAAAAAGGAAATGCAGGGATCAAGAGTGCGATTTTTCAATGCTGAAATTAATCACACAATAT
TAATGCATCGCCCACATCCAGAAAGTTATATTAAAGGTGGAACGCTGAAAGCTATTAAACAGAACTTGAAAGAGGCTGGG
GTTTTATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8511.42 Da        Isoelectric Point: 4.3719

>AT206733 WP_186679048.1 NZ_CP077093:c4425613-4425383 [Pseudomonas vanderleydeniana]
MEQGSVFQSNRSQAVRLPKAVALPDEVKRVDVVAIGRTRIITPAGESWDSWFNDSGVTADFMTDREQPADQEREAF

Download         Length: 231 bp

>AT206733 NZ_CP102672:c33197-32850 [Escherichia coli]
ATGAAACATTTAAAATATAAAGGATATTTAGGTACGGTTGAGCCGGATTTTGAAAATAATATCCTGTATGGAAAGCTGGC
ATTTATTCGTGATCTGGTGACTTATGAGGCAGAAACATTGGCTGACCTGGAACGGGAATTTAAAACATCGGTTGATTTGT
ATTTACAGTCCTGTGTGGAGGACGGAAAGGAGCCTGACACGCCCTTTAAAGGTGTGTTTAACGTCAGGCTTGATCCAGAG
CTGCATCGTCGGGTCGCTGAAATGGCGATGGAAGAAGATTTGTCGCTGAATGCCTTTGTCAATAAGGCACTGGAAAAAGA
AGTCAGTCATCATCGCGCAGGGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References