206732

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 2971395..2972041 Replicon chromosome
Accession NZ_CP077093
Organism Pseudomonas vanderleydeniana strain RW8P3

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag HU752_RS13455 Protein ID WP_186680103.1
Coordinates 2971395..2971814 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag HU752_RS13460 Protein ID WP_186680114.1
Coordinates 2971811..2972041 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU752_RS13425 (HU752_013425) 2966533..2967753 + 1221 WP_186680090.1 putative DNA modification/repair radical SAM protein -
HU752_RS13430 (HU752_013430) 2967750..2968610 + 861 WP_186680093.1 TIGR03915 family putative DNA repair protein -
HU752_RS13435 (HU752_013435) 2968627..2969283 - 657 WP_186680096.1 oxygen-insensitive NAD(P)H nitroreductase -
HU752_RS13440 (HU752_013440) 2969390..2970307 + 918 WP_186680100.1 LysR family transcriptional regulator -
HU752_RS13450 (HU752_013450) 2970932..2971444 + 513 WP_202894681.1 hypothetical protein -
HU752_RS13455 (HU752_013455) 2971395..2971814 - 420 WP_186680103.1 type II toxin-antitoxin system VapC family toxin Toxin
HU752_RS13460 (HU752_013460) 2971811..2972041 - 231 WP_186680114.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
HU752_RS13465 (HU752_013465) 2972381..2973688 - 1308 WP_186680118.1 cytochrome c -
HU752_RS13470 (HU752_013470) 2973700..2975475 - 1776 WP_186680122.1 GMC family oxidoreductase -
HU752_RS13475 (HU752_013475) 2975567..2976283 - 717 WP_186680125.1 gluconate 2-dehydrogenase subunit 3 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-129)

Antitoxin

SpoVT-AbrB domain

(7-43)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15166.34 Da        Isoelectric Point: 6.4491

>T206732 WP_186680103.1 NZ_CP077093:c2971814-2971395 [Pseudomonas vanderleydeniana]
VTTYMLDTCICSFIMREQPASVIQRLTTEVERGNRIVISAITYAEMRYGQIGKKASAKHKPLVDEFVKRLDAILAWDQNA
VDATIGVKCKLTESGSPIGPNDTAIAGHAIASGCTLVTNNVREFSRVAGLDYEDWVATS

Download         Length: 420 bp

>T206732 NZ_CP102670:89467-89772 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCAGTTTAAGGTTTACACCTGTAAAAGGGAGAGTCGCTACCGGCTGTTTGTGGACGTGCAGAGCGACATCATTGACAC
CCCCGGACGGCGGATGGCTGTCCCGCTGGTCAGCGCCCGTCTGCTGTCGGAAAAGGTTCCCCGCGATCTTTACCCGGTGA
TGCATATCGGGGATGAGCCTTACCGCCTGCTGACCACGGATATGACCAGTGTGCCGGCCACCGTCATCGGGGAAGAGGTG
GCCGATCTCAGCCTCCGGGAGAACGATATCAAAAACGCCATTAACCTGATGTTCCGGGGGATCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8397.45 Da        Isoelectric Point: 4.7247

>AT206732 WP_186680114.1 NZ_CP077093:c2972041-2971811 [Pseudomonas vanderleydeniana]
MRTVSIFKNGKNQAVRLPADMAYDGVGELEISREGDVITLRPARPSWSSFSEVAKADADFLQERPAVIGDEGRFNL

Download         Length: 231 bp

>AT206732 NZ_CP102670:89247-89465 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAAGCAGCGAATTACAGTGACAGTGGACAGCGACAGCTATCAGCTGCTCAAGGCATACGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGAGCCGAACGCTGGCAGGAAGAAAATCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATAGAGGCTAACGGATCGTTTGCTGACGACAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References