Detailed information of TA system TA206731

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2294258..2294868
• Replicon: chromosome
• Accession: NZ_CP077093
• Organism: Pseudomonas vanderleydeniana strain RW8P3

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HU752_RS10340
• Protein ID: WP_017906656.1
• Coordinates: 2294686..2294868 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A9E6PPM1
• Locus tag: HU752_RS10335
• Protein ID: WP_026145577.1
• Coordinates: 2294258..2294662 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HU752_RS10320 (HU752_010320)	2291910..2292380	+	471	WP_186681751.1	DUF1289 domain-containing protein	-
HU752_RS10325 (HU752_010325)	2292581..2293441	-	861	WP_186681750.1	universal stress protein	-
HU752_RS10330 (HU752_010330)	2293659..2294261	+	603	WP_186681748.1	tRNA isopentenyl-2-thiomethyl-A-37 hydroxylase MiaE	-
HU752_RS10335 (HU752_010335)	2294258..2294662	-	405	WP_026145577.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HU752_RS10340 (HU752_010340)	2294686..2294868	-	183	WP_017906656.1	type II toxin-antitoxin system HicA family toxin	Toxin
HU752_RS10345 (HU752_010345)	2295177..2295659	+	483	WP_186681746.1	MarR family transcriptional regulator	-
HU752_RS10350 (HU752_010350)	2295649..2297118	+	1470	WP_186681744.1	efflux transporter outer membrane subunit	-
HU752_RS10355 (HU752_010355)	2297134..2298336	+	1203	WP_186681742.1	HlyD family efflux transporter periplasmic adaptor subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6752.90 Da
• Isoelectric Point: 11.5494

>T206731 WP_017906656.1 NZ_CP077093:c2294868-2294686 [Pseudomonas vanderleydeniana]
VKSRDLIAELEAAGWMLQRIRGSHHVFVHENSPHSIPVPHPKKDLPLGTVRSIRKRAGLL

Nucleotide

• Length: 183 bp

>T206731 NZ_CP102670:c62186-61788 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCTGAAGTTTATGCTGGATACTAACATCTGCATTTTCACGATAAAAAACAAACCTGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGCTCGGTCACCCTGATGGAGCTGATTTACGGCGCCGAAAAAAGCCAGATGCCCG
AAAGAAATCTCGCTGTGATAGAGGGGTTTGTTTCCCGACTTGATGTTCTGGATTATGACACGCCGGCCGCCACCCATACG
GGGCAGATCAGGGCAGAGCTTGCCCGTCAGGGACGCCCTGTCGGGCCATTCGATCAGATGATTGCCGGTCACGCACGCAG
CCGGGGACTGATTGTTGTCACGAACAACACCCGGGAGTTTGAACGTGTGGGTGGACTGAGAACTGAGGACTGGAGCTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14819.79 Da
• Isoelectric Point: 4.4041

>AT206731 WP_026145577.1 NZ_CP077093:c2294662-2294258 [Pseudomonas vanderleydeniana]
MQYPIAIEWGDENTAIGIQVPDIPGAVTAGDTFEEAYNAAIEVAHIMLEEIASSGEPVPMPSSSFTHRQNPEFADMGWGM
LEIDISPYLGKTEKVNVTLPGFVIQRIDRYVRDHRIKSRSSFLADAALEKLVRA

Nucleotide

• Length: 405 bp

>AT206731 NZ_CP102670:c62413-62186 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGAAACCAGCGTATTTCTCAGTAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCAGTGGCTTTGCCGGAAAATGTAAA
ACGTGTGGAAGTTATCGCTGTCGGGCGAACCCGAATTATCACGCCGGCCGGAGAATCGTGGGATGAATGGTTCGACGGGA
ACAACGTCAGCGCCGATTTTATGGATAACCGGGAACAACCCTCTGTGCAGGAACGGGAATCATTCTGA