Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/PRK09812-MazE |
Location | 729861..730492 | Replicon | chromosome |
Accession | NZ_CP077093 | ||
Organism | Pseudomonas vanderleydeniana strain RW8P3 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | - |
Locus tag | HU752_RS03270 | Protein ID | WP_186683247.1 |
Coordinates | 730130..730492 (+) | Length | 121 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | - |
Locus tag | HU752_RS03265 | Protein ID | WP_186683245.1 |
Coordinates | 729861..730130 (+) | Length | 90 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HU752_RS03230 (HU752_003230) | 725173..725718 | - | 546 | WP_186683234.1 | hypothetical protein | - |
HU752_RS03235 (HU752_003235) | 725715..725969 | - | 255 | WP_054060673.1 | acyl carrier protein | - |
HU752_RS03240 (HU752_003240) | 725979..726251 | - | 273 | WP_186683235.1 | phosphopantetheine-binding protein | - |
HU752_RS03245 (HU752_003245) | 726220..727038 | - | 819 | WP_186683237.1 | lysophospholipid acyltransferase family protein | - |
HU752_RS03250 (HU752_003250) | 727014..727733 | - | 720 | WP_186683240.1 | beta-ketoacyl synthase chain length factor | - |
HU752_RS03255 (HU752_003255) | 728097..728870 | + | 774 | WP_186683242.1 | ParA family protein | - |
HU752_RS03260 (HU752_003260) | 728867..729307 | - | 441 | WP_186683244.1 | thioredoxin TrxC | - |
HU752_RS03265 (HU752_003265) | 729861..730130 | + | 270 | WP_186683245.1 | PbsX family transcriptional regulator | Antitoxin |
HU752_RS03270 (HU752_003270) | 730130..730492 | + | 363 | WP_186683247.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
HU752_RS03275 (HU752_003275) | 730497..731960 | - | 1464 | WP_186683249.1 | YdiU family protein | - |
HU752_RS03280 (HU752_003280) | 732014..735367 | - | 3354 | WP_186683251.1 | mechanosensitive channel MscK | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 121 a.a. Molecular weight: 13384.39 Da Isoelectric Point: 7.1358
>T206729 WP_186683247.1 NZ_CP077093:730130-730492 [Pseudomonas vanderleydeniana]
MVRRQAPQRGDVYWIDPNPVAGREMMNRHRFVVITPREINALGVSMTVPITTGGSFSRNSGLAVIVTGHETNGVALCNQV
RSFDIEQRVRDGSAKFIERLDDITMMDIVCRVVSVIDPEV
MVRRQAPQRGDVYWIDPNPVAGREMMNRHRFVVITPREINALGVSMTVPITTGGSFSRNSGLAVIVTGHETNGVALCNQV
RSFDIEQRVRDGSAKFIERLDDITMMDIVCRVVSVIDPEV
Download Length: 363 bp
>T206729 NZ_CP102669:c4764674-4764363 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG
Antitoxin
Download Length: 90 a.a. Molecular weight: 9659.34 Da Isoelectric Point: 8.6594
>AT206729 WP_186683245.1 NZ_CP077093:729861-730130 [Pseudomonas vanderleydeniana]
MSVTSKIRRQGGAAVMTIPPTLLKLLHLDVGAQLELKVVDGELIAKPMIRPARKRYSLTELLQGAEAIVELNAETAWARE
GDPVGREIG
MSVTSKIRRQGGAAVMTIPPTLLKLLHLDVGAQLELKVVDGELIAKPMIRPARKRYSLTELLQGAEAIVELNAETAWARE
GDPVGREIG
Download Length: 270 bp
>AT206729 NZ_CP102669:c4764362-4764072 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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