Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09812-MazE
Location 729861..730492 Replicon chromosome
Accession NZ_CP077093
Organism Pseudomonas vanderleydeniana strain RW8P3

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag HU752_RS03270 Protein ID WP_186683247.1
Coordinates 730130..730492 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag HU752_RS03265 Protein ID WP_186683245.1
Coordinates 729861..730130 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HU752_RS03230 (HU752_003230) 725173..725718 - 546 WP_186683234.1 hypothetical protein -
HU752_RS03235 (HU752_003235) 725715..725969 - 255 WP_054060673.1 acyl carrier protein -
HU752_RS03240 (HU752_003240) 725979..726251 - 273 WP_186683235.1 phosphopantetheine-binding protein -
HU752_RS03245 (HU752_003245) 726220..727038 - 819 WP_186683237.1 lysophospholipid acyltransferase family protein -
HU752_RS03250 (HU752_003250) 727014..727733 - 720 WP_186683240.1 beta-ketoacyl synthase chain length factor -
HU752_RS03255 (HU752_003255) 728097..728870 + 774 WP_186683242.1 ParA family protein -
HU752_RS03260 (HU752_003260) 728867..729307 - 441 WP_186683244.1 thioredoxin TrxC -
HU752_RS03265 (HU752_003265) 729861..730130 + 270 WP_186683245.1 PbsX family transcriptional regulator Antitoxin
HU752_RS03270 (HU752_003270) 730130..730492 + 363 WP_186683247.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
HU752_RS03275 (HU752_003275) 730497..731960 - 1464 WP_186683249.1 YdiU family protein -
HU752_RS03280 (HU752_003280) 732014..735367 - 3354 WP_186683251.1 mechanosensitive channel MscK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13384.39 Da        Isoelectric Point: 7.1358

>T206729 WP_186683247.1 NZ_CP077093:730130-730492 [Pseudomonas vanderleydeniana]
MVRRQAPQRGDVYWIDPNPVAGREMMNRHRFVVITPREINALGVSMTVPITTGGSFSRNSGLAVIVTGHETNGVALCNQV
RSFDIEQRVRDGSAKFIERLDDITMMDIVCRVVSVIDPEV

Download         Length: 363 bp

>T206729 NZ_CP102669:c4764674-4764363 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9659.34 Da        Isoelectric Point: 8.6594

>AT206729 WP_186683245.1 NZ_CP077093:729861-730130 [Pseudomonas vanderleydeniana]
MSVTSKIRRQGGAAVMTIPPTLLKLLHLDVGAQLELKVVDGELIAKPMIRPARKRYSLTELLQGAEAIVELNAETAWARE
GDPVGREIG

Download         Length: 270 bp

>AT206729 NZ_CP102669:c4764362-4764072 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References